Found 116 Surgery trials
A listing of Surgery medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Preoperative use of radiation boost to enhance effectiveness of immune checkpoint blockade therapy in operable breast cancer
Our study is a Phase 1Ib/2 clinical trial to evaluate the safety and feasibility of the combination of radiotherapy (RT) in a single fraction of 7 Gy with pembrolizumab in patients with operable breast cancer. We will employ a Simon Two Stage design to evaluate the safety, feasibility, and efficacy …
SPOTLITE: Study of Surgical Interventions in Complex Fistulizing Conditions (CPF-CD CD-RVF CCF)
An observational study that aims to collect data over time on the effect of surgery on patient's with a complex fistulizing condition such as: • complex perianal fistula with Crohn’s Disease (CPF-CD) • rectovaginal fistula with Crohn’s Disease (CD-RVF), or • complex cryptoglandular fistulas (CCF). The study will follow patients …
A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.
The purpose of this study is to evaluate the safety and efficacy of CNTX-6970. The target population is adults between 40 - 90 years old who have moderate to severe knee pain related to OA. The study drug is being compared to Celebrex, an FDA approved drug used to treat …
Corcym Mitral Aortic and Tricuspid post-market study in a real-world setting
This research study is being conducted to collect information on those who have been diagnosed with a disease related to a heart valve dysfunction or abnormality, needing surgical repair, or replacement of the affected valve. This research study is collecting information about the disease and the treatment. Participants will be …
A Phase 2 Study for the Evaluation of Safety and Efficacy of Humacyte's Human Acellular Vessel for Vascular Replacement or Reconstruction in Patients with Life or Limb-threatening Vascular Trauma
This is a prospective, multicenter, multi-cohort (limb and torso), non-randomized study designed to evaluate the safety and tolerability of the Humacyte HAV in vascular trauma patients undergoing surgery for vascular replacement or reconstruction. The University of Pennsylvania will participate as a site by enrolling subjects between the ages of 18 …
Multimodality MRI and Liquid Biopsy in Gliblastoma
We are seeking to enroll up to 30 subjects with newly diagnosed or recurrent GBM who will undergo a clinical brain MRI examination with and without contrast prior to surgery. Participants will also have a blood draw pre-operatively to collect samples for cfDNA and ctDNA analysis. MRI imaging will include …
A study to establish the diagnostic performance of 18F-fluciclovine positron emission tomography (PET) in detecting recurrent brain metastases after radiation therapy (REVELATE)
The research study is being conducted to show how effective an imaging drug called 18F-fluciclovine can be used to image uptake before planned surgery. Fluciclovine is a drug used with an imaging test called Positron Emission Tomography/Computed Tomography (PET/CT). PET scan is for detecting suspected recurrence of brain metastases in …
Evaluation of Outcomes from Treatment of Benign or Malignant Gastroesophageal Diseases
This study will be a retrospective chart review of patients who have been diagnosed with benign or malignant pancreatic disease under the practice of Dr. Rohan Jeyarajah, M.D., Dr. Houssam Osman M.D., and Dr. Edward Cho M.D., Sc.M. at Methodist Health System Hospital in Richardson, Texas. The Investigators plan to …
Study to evaluate drug BGB-290 with Temozolomide in Recurrent Gliomas with IDH1/2 Mutations
This study is being done to determine how well the study drug, BGB-290, gets into the brain tumor and to confirm if we can continuously and safely give BGB-290 and temozolomide as a combination treatment after surgery. We are testing a dose of temozolomide once a day combined with the …
MUSA- Treatment for Mixed Urinary Incontinence: Mid-urethral Sling vs. Botox A
Mixed urinary incontinence (MUI), defined as the presence of both stress urinary incontinence and urgency urinary incontinence, is a challenging condition for which clinicians frequently use multiple sequential treatments that have undergone limited head to head comparison in rigorous clinical trials. Mid-urethral Sling vs. Botox A (MUSA) is a randomized …
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