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Found 105 medicine trials

A listing of medicine medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 A Clinical Trial to Evaluate the Safety and Efficacy of Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor
99 years or below
All genders
The Exablate Model 4000 Type-1.0/1.1 Neuro system involves using an advanced, non-invasive technique currently approved by the Food and Drug Administration (FDA) to treat one side of your brain in a procedure called a thalamotomy (lesion the thalamus). This procedure involves performing an ablation (lesion) of an area of the …
 ASPEN- A Phase 3  Randomized  Double-Blind  Placebo-Controlled Study to Assess the Efficacy  Safety  and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects With Non-Cystic Fibrosis Bronchiectasis
18 years - 85 years
All genders
Phase 3
Interventional
Penn Medicine patients already participating in protocol INS1007 301 will be invited to participate in this study. The Pharmacokinetic (PK) portion of this substudy is designed to evaluate the amount of brensocatib present in your blood at certain time periods before and after the study drug is administered, and the …
 Phase IV Open Label Study of the Effects of Secukinumab on Nail Psoriasis and non-invasive measures of enthesitis
18 years - 99 years
All genders
Phase 4
The purpose of this study is to determine how psoriatic nail disease is affected by secukinumab. Secukinumab (Cosentyx®) is a prescription medicine that has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of plaque psoriasis, active psoriatic arthritis, and active ankylosing spondylitis in adults. While …
 ONC201 in recurrent high-grade glioma
18 years - 99 years
All genders
Phase 2
This is a phase II, open-label study of ONC201 in adults with recurrent high- grade glioma. Subjects for this study will be recruited from the patient population that present to the Penn Brain tumor center- Department of Neurosurgery or Department of Medicine division of Hematology/ Oncology for evaluation and treatment …
 Cooling to Help Injured lungs (CHILL) for  Therapeutic Hypothermia in Patients with ARDS (acute respiratory distress syndrome )
18 years - 65 years
All genders
Phase 2
This study will analyze the potential lung protective effect of mild therapeutic hypothermia (TH), similar to that used for cardiac arrest, in ICU patients with acute respiratory distress syndrome (ARDS).
 A Randomized Study to Compare Efficacy  Safety  and Tolerability of Macitentan 75mg Versus Macitentan 10mg in Patients with Pulmonary Arterial Hypertension  Followed by an Open-label Treatment Period with Macitentan 75mg
18 years - 75 years
All genders
Phase 3
TThe research study is being conducted to compare macitentan 75 mg with the approved macitentan 10 mg to see if it is well tolerated, safe and useful for treating patients with pulmonary arterial hypertension (PAH).
 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis
40 years - 99 years
All genders
This study is looking to see if inhaled treprostinil helps patients with IPF improve their pulmonary function tests. Patients will randomized to either placebo or inhaled treprostinil and will also undergo the following throughout the study: PFTs, physical exams, EKGs, HRCT, questionnaires, vital signs, lab tests
 PEERLESS Study
99 years or below
All genders
The FlowTriever Retrieval/Aspiration System (referred to as “FlowTriever”) is an FDA-cleared device designed to treat pulmonary embolism (PE). A PE is a blood clot trapped in your lung. The FlowTriever is used to remove the clot by pulling it into a catheter so that the clot can be removed from …
 Exploratory Study of Mavacamten (MYK-461) in Patients with Symptomatic Non-obstructive Hypertrophic Cardiomyopathy (nHCM) and Preserved Left Ventricular Ejection Fraction
18 years - 99 years
All genders
Phase 2
The purpose of this study is to compare the effect of the investigational drug, mavacamten, (MYK-461), to a placebo (an inactive substance) in patients with Non-obstructive Hypertrophic Cardiomyopathy (nHCM).
 UPCC 15518 / ANAM-17-21: A Phase 3  Randomized  Double-Blind  Placebo-Controlled  Multicenter Study to Evaluate the Efficacy and Safety of anamorelin HCl for the Treatment of Malignancy Associated Weight Loss and Anorexia in Adult Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
18 years - 99 years
All genders
Phase 3
The main purpose of this study is to learn more about how well the experimental drug, anamorelin hydrochloride (HCl), works to prevent weight loss and anorexia in patients with advanced Non-Small Cell Lung Cancer.
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