Clinical Research
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Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate
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Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.
Recently added/updated trials
A Randomized, Placebo-controlled, Double-blind, Multicenter Study to Assess the Efficacy and Safety of Nipocalimab in Adults with Primary Sjogren's Syndrome (pSS)
The purpose of this study is to evaluate the efficacy and safety of nipocalimab in
participants with primary Sjogren's syndrome (pSS) versus placebo.
An Extension Study to Assess the Long-Term Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB067 Administered to Previously Treated Adults with Amyotrophic Lateral Sclerosis Caused by Superoxide Dismutase 1 Mutation
The primary objective of the study is to evaluate the long-term safety and tolerability
of BIIB067 (tofersen) in participants with amyotrophic lateral sclerosis (ALS) and
confirmed superoxide dismutase 1 (SOD1) mutation. The secondary objectives are to
evaluate the pharmacokinetic (PK), pharmacodynamic (PD), biomarker effects, and efficacy
of BIIB067 administered to participants with ALS and a confirmed SOD1 mutation.
Estimation of Steatosis on Liver Transplants by Intraoperative Spectrometry
The goal is to have a small spectrometer (pocket size) , reliable and rapid tool that can
be used during liver harvesting, which enables macrosteatosis to be evaluated
reproducibly and selectively, at any time.
This tool must be minimally invasive, inexpensive and without significantly impacting the
general organization of multi-organ harvesting.
In the operating room, the surgeon will perform an intraoperative spectrometer scan (five
scans on the left lobe) before clamping the aorta. The surgeon will not be informed of
the results of the spectrometer, and will carry out (or not) the biopsy. The
spectrometers' results will be compared with definitive histological findings.
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