Found 64 Metastatic Cancer trials
A listing of Metastatic Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Study to Evaluate LevoCept, a Long-Acting Reversible Intrauterine System, for Contraceptive Efficacy Safety and Tolerability.
The primary objective of the study is to assess the contraceptive efficacy (prevention of pregnancy) of LevoCept. The secondary objectives of the study are to assess the following for LevoCept: Safety and tolerability; Return to fertility after LevoCept removal, only for subjects requesting LevoCept removal to become pregnant; Release rate …
Randomized Double-Blind Placebo-Controlled Proof of Concept Study to Assess the Safety and Efficacy of Elezanumab in Acute Traumatic Cervical Spinal Cord Injury
The objectives of the study are to assess the safety and efficacy of elezanumab in subjects with acute traumatic cervical SCI. The primary endpoint is the Upper Extremity Motor Score (UEMS), a subscore of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI, 2019 criteria) during the treatment …
Continued Access Protocol Study for The Use of the OrganOx Metra Normothermic Machine Perfusion Device in Human Liver Transplantation
The primary objective of the study is to assess the effect of preventing preservation-related graft injury with the use of the metra® device in enrolled subjects. The single-arm continued access phase will be used to collect additional effectiveness and safety data to support the objectives and outcomes of the original …
Immune Impact of Bevacizumab in Patients with Recurrent Glioblastoma
PURPOSE/DESCRIPTION: Primary: to perform high-dimensional flow cytometry on peripheral blood of patients with recurrent glioblastoma receiving standard of care anti-VEGF therapy with bevacizumab to understand the immune impact of the drug on various immune cell populations. Secondary: To perform an evaluation of ex vivo cytokine production in peripheral blood T …
MIRASOL: A Randomized Open-label Phase 3 Study of Mirvetuximab Soravtansine vs. Investigators Choice of Chemotherapy in Advanced High- Grade Epithelial Ovarian Primary Peritoneal or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression
The primary objective is to compare the PFS of patients randomized to MIRV vs. IC Chemo. Secondary objectives include: To compare the ORR of patients randomized to MIRV vs. IC Chemo, to compare OS of patients randomized to MIRV vs. IC Chemo, and to compare the primary patient-reported outcome (PRO) …
PPS Study- Screening and Classification of Pentosan-Associated Maculopathy in Patients with Interstitial Cystitis
The primary objective of this study is to determine the prevalence of retinal changes in patients using pentosan polysulfate sodium (PPS) for treatment of interstitial cystitis and further characterize this condition using multimodal imaging. Additionally, this study aims to identify additional clinical findings associated with PPS maculopathy and to gain …
Evaluating the efficacy and safety of IPH4102 with chemotherapy in patients with advanced T-cell lymphoma
This research study is being conducted to assess the safety and efficacy of IPH4102, an investigative medication (medication not approved by the Food and Drug Administration (FDA) for subjects diagnosed with Sézary Syndrome (SS) or Mycosis Fungoides (MF) over the age of 18. Participants will be asked to complete the …
A Prospective Multicenter Non-Blinded Non-Randomized Study of the Relay PRO Thoracic Stent-Graft in Subjects with Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers
The primary safety objective is a composite of the number of Major Adverse Events (MAEs) occurring through 30 days post-procedure compared to the rate in subjects treated with the Relay Thoracic Stent-Graft in the U.S. Pivotal Trial (P110038). The primary effectiveness objective is a composite of the number of effectiveness …
PTAAK- study of pulse wave velocity evaluation tacrolimus time in therapeutic range and co-efficient of tacrolimus variation of African American kidney transplant recipients receiving immediate release tacrolimus capsules (IR-Tac) or extended release tacrolimus tablets (LCPT)
The primary purpose of this study is to evaluate the pulse wave velocity and vascular compliance measurements at the beginning and the end of the study in African American kidney transplant recipients taking either Envarsus XR® (extended release tacrolimus) tablets administered once-daily after transplantation or immediate release generic tacrolimus capsules …
ONC201 in recurrent high-grade glioma
This is a phase II, open-label study of ONC201 in adults with recurrent high- grade glioma. Subjects for this study will be recruited from the patient population that present to the Penn Brain tumor center- Department of Neurosurgery or Department of Medicine division of Hematology/ Oncology for evaluation and treatment …
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