Found 40 Heart Failure trials
A listing of Heart Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Skeletal Muscle Perfusion and Mitochondrial Function in Heart Failure with Preserved Ejection Fraction
The study is being conducted to understand why the skeletal muscle of patients with Heart Failure with Preserved Ejection Fraction (HFpEF) does not work as well as the muscle of individuals without heart failure. This study seeks to understand whether the problem is with blood and oxygen delivery to the …
Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure
Randomized (flip of the coin 50/50) study of heart failure (HF) patients with moderate aortic valve stenosis (narrowing) will be either treated with a transcatheter valve replacement (TAVR) or continue with medical management. Subjects will be followed for 2 years. We will collect information regarding death and major events such …
Assessment of the CARILLON Mitral Contour System in Treating Functional Mitral Regurgitation Associated with Heart Failure
Prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the CARILLON Mitral Contour System in treating functional mitral regurgitation associated with heart failure.
Early Feasibility Study of the AccuCinch Ventricular Repair System in Patients with Heart Failure and Reduced Ejection Fraction (HFrEF)
This is a research study sponsored by Ancora Heart, Inc. that will assess the safety and feasibility of the AccuCinch® Ventricular Repair System. This investigational (experimental) device is designed to treat patients who are experiencing symptoms of heart failure due to a dilated left ventricle (heart chamber that pumps blood).
Magnetic Resonance Imaging Based Risk Stratification for Defibrillator Implantation in Heart Failure Patients Requiring Cardiac Resynchronisation Therapy-published version (MADURAI CRT)
This randomized study aimed to compare the efficacy of LBBP without defibrillator vs biventricular pacing with defibrillator (BiV-ICD/CRT-D) in patients with LB-NICM and left ventricular ejection fraction (LVEF) ≤35% risk categorized by CMR imaging.
BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in Heart Failure with Preserved Ejection Fraction
The purpose of the study is to compare how amlodipine versus metoprolol effect blood pressure in people with HFpEF. While hypertension is the most common risk factor for HFpEF, there is little evidence on the potential role of common antihypertensive medications, specifically calcium channel blockers (like amlodipine) and β-blockers …
Attain StarFix Model 4195 LV Lead Extraction Study
The purpose of this study is to characterize the removability of the Attain StarFix®Model 4195 Left Ventricular (LV) Lead (StarFix®). The goal of the trial is to evaluate the lead removal success in patients that are indicated for left ventricular lead removal. This study is required by the Food and …
Open-Labeled Trial Of Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors
Since 2006, there has been a 50% increase in the number of adults added to the heart transplant waitlist in the US. Yet the persistent organ donor shortage has led to only a 25% increase in the number of transplants, and a 25% increase in the number of patients removed …
Matching Perfusion and Metabolic Activity in HFpEF
This study will test whether Potassium Nitrate (KNO3), with and without Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR), improves submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF). This study will also test whether the response to supplemental oxygen …
AN EXPLORATORY OPEN-LABEL PROOF-OF-CONCEPT PHASE 2A STUDY OF MAVACAMTEN (MYK-461) IN PARTICIPANTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF) AND CHRONIC ELEVATION OF CARDIAC TROPONIN I AND/OR NT-PROBNP
This is a multicenter, exploratory, open-label study to explore the efficacy and/or pharmacodynamic effect, PK, safety, and tolerability of mavacamten in approximately 35 ambulatory participants with symptomatic HFpEF and elevated cTnI and/or elevated NT-proBNP as defined in inclusion/exclusion criteria. The study will include an up to 7-week screening period (with …
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