Found 39 Heart Failure trials
A listing of Heart Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
The study is being conducted to understand why the skeletal muscle of patients with Heart Failure with Preserved Ejection Fraction (HFpEF) does not work as well as the muscle of individuals without heart failure. This study seeks to understand whether the problem is with blood and oxygen delivery to the …
Randomized (flip of the coin 50/50) study of heart failure (HF) patients with moderate aortic valve stenosis (narrowing) will be either treated with a transcatheter valve replacement (TAVR) or continue with medical management. Subjects will be followed for 2 years. We will collect information regarding death and major events such …
Prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the CARILLON Mitral Contour System in treating functional mitral regurgitation associated with heart failure.
This is a research study sponsored by Ancora Heart, Inc. that will assess the safety and feasibility of the AccuCinch® Ventricular Repair System. This investigational (experimental) device is designed to treat patients who are experiencing symptoms of heart failure due to a dilated left ventricle (heart chamber that pumps blood).
The purpose of the study is to compare how amlodipine versus metoprolol effect blood pressure in people with HFpEF. While hypertension is the most common risk factor for HFpEF, there is little evidence on the potential role of common antihypertensive medications, specifically calcium channel blockers (like amlodipine) and β-blockers …
The purpose of this study is to characterize the removability of the Attain StarFix®Model 4195 Left Ventricular (LV) Lead (StarFix®). The goal of the trial is to evaluate the lead removal success in patients that are indicated for left ventricular lead removal. This study is required by the Food and …
Since 2006, there has been a 50% increase in the number of adults added to the heart transplant waitlist in the US. Yet the persistent organ donor shortage has led to only a 25% increase in the number of transplants, and a 25% increase in the number of patients removed …
This study will test whether Potassium Nitrate (KNO3), with and without Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR), improves submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF). This study will also test whether the response to supplemental oxygen …
This is a multicenter, exploratory, open-label study to explore the efficacy and/or pharmacodynamic effect, PK, safety, and tolerability of mavacamten in approximately 35 ambulatory participants with symptomatic HFpEF and elevated cTnI and/or elevated NT-proBNP as defined in inclusion/exclusion criteria. The study will include an up to 7-week screening period (with …
The HeartMate 3 requires medicines to keep your blood from clotting knowing as “blood thinners” which can both be anticoagulants and antiplatelet drugs. The standard drugs given when you have the HeartMate 3 are warfarin and aspirin. This study is investigating whether the combination of these drugs as compared to …
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