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Found 55 transplant trials

A listing of transplant medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide (ACCESS)
1 year or above
All genders
Phase 2
Interventional
This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. Post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate mofetil (MMF) will be used for for …
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Online study
18 years - 70 years
All genders
Phase 3
Interventional
The purpose of this study is to demonstrate the efficacy and safety of imlifidase in comparison to the standard of care (SoC) in the management of highly sensitized transplant patients.
 A study to assess the safety and tolerability of nebulized PC945 for prophylaxis or pre-emptive therapy against pulmonary aspergillosis in lung transplant recipients.
18 years - 99 years
All genders
Phase 2
Interventional
The purpose of this study is to learn about how safe and effective a new investigational drug, PC945, can be. An investigational drug is one that is not approved by the United States Food and Drug Administration (FDA). PC945 is an inhaled drug being studied for the prevention of a …
21 years - 40 years
Female
The UNTIL Trial is a new clinical research trial that offers uterine transplantation to women with uterine factor infertility (UFI). Participation in this trial requires going through an extensive selection process, creation of embryos through in vitro fertilization, and multiple surgeries. Study participants may remain in the study for 5-10 …
 TruGraf Long-term Clinical Outcomes Study
18 years - 99 years
All genders
Observational
The purpose of this study is to evaluate post-transplant clinical outcomes in recipients of kidney transplants who are undergoing TruGraf® and TRAC monitoring. These tests are commercially available blood tests that may help better monitor rejection. Targeted population are kidney transplant recipients. Procedures include blood will be drawn for TruGraf® …
 Open-Labeled Trial Of Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors
99 years or below
All genders
Phase 2
Since 2006, there has been a 50% increase in the number of adults added to the heart transplant waitlist in the US. Yet the persistent organ donor shortage has led to only a 25% increase in the number of transplants, and a 25% increase in the number of patients removed …
 A trial of transplanting Hepatitis C-viremic kidneys into Hepatitis C-Negative kidney recipients
99 years or below
All genders
Phase 2
The THINKER-NEXT research study is being done to determine whether it is safe to give a kidney transplant from a donor with hepatitis C to a patient without hepatitis C. The recipient will then be given a drug called Epclusa for 12 weeks to treat hepatitis C. Patients who are …
 A Randomized  Multicenter  Phase III Trial of Tacrolimus/Methotrexate versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation
18 years - 99 years
All genders
Interventional
This study compares 2 combinations of drugs to prevent graft-versus-host disease (GVHD): Tacrolimus/methotrexate and Tacrolimus/mycophenolate mofetil/cyclophosphamide. Doctors want to know which combination is better or if they give the same results. The study will help doctors decide which treatment is best for future transplant patients. The purpose of its companion …
99 years or below
All genders
Using a pilot cohort, we hope to estimate tac PK parameters and conduct simulation studies to support design of a multicenter study to develop and validate a robust post-lung transplant tac population pharmacokinetic (popPK) model. The primary outcome will be the area under the concentration-time curve (AUC), which will provide …
 PTAAK- study of pulse wave velocity evaluation  tacrolimus time in therapeutic range and co-efficient of tacrolimus variation of African American kidney transplant recipients receiving immediate release tacrolimus capsules (IR-Tac) or extended release tacrolimus tablets (LCPT)
18 years - 75 years
All genders
Phase 4
The primary purpose of this study is to evaluate the pulse wave velocity and vascular compliance measurements at the beginning and the end of the study in African American kidney transplant recipients taking either Envarsus XR® (extended release tacrolimus) tablets administered once-daily after transplantation or immediate release generic tacrolimus capsules …
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