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Found 105 medicine trials

A listing of medicine medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 JK07 in Subjects with Heart Failure with Reduced Ejection Fraction (HFrEF)
18 years - 80 years
All genders
Phase 1
Patients with Heart Failure with Reduced Ejection Fraction (HFrEF) will be invited to participate in this study. HFrEF is a condition in which the heart pumps a lower than normal amount of blood. The purpose of this study is to evaluate the safety and activity of the investigational product in …
99 years or below
All genders
This Post Approval Study is a multi-center, prospective, open label, single arm cohort study to evaluate the long-term safety, long-term effectiveness, and survival rate in subjects implanted with the remed System from the remed System Pivotal Trial. Up to 94 subjects will be enrolled at up to 21 sites in …
 Dapagliflozin Effect on symptoms and blomarkers in patients with Heart Failure (DEFINE-HF)
18 years - 100 years
All genders
Interventional
The purpose of this study is to find out if a drug called dapagliflozin would be effective in improving the blood tests and symptoms related to your heart failure.
 BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in Heart Failure with Preserved Ejection Fraction
18 years - 99 years
All genders
Phase 1
The purpose of the study is to compare how amlodipine versus metoprolol effect blood pressure in people with HFpEF.   While hypertension is the most common risk factor for HFpEF, there is little evidence on the potential role of common antihypertensive medications, specifically calcium channel blockers (like amlodipine) and β-blockers …
 Medtronic SMall Annuli Randomized To Evolut or Sapien Trial (SMART Trial)
18 years - 99 years
All genders
The purpose of this study is to collect information and compare the safety and performance of self-expanding (SE) versus balloon-expandable (BE) transcatheter aortic valve replacement (TAVR) in patients with a small aortic valve.Study participants will be randomized on a 1:1 basis to receive transcatheter aortic valve replacement (TAVR) with either …
 TIME- Text-based intervention to minimize the time burden of routine cancer care
18 years - 99 years
All genders
The research study is being conducted to evaluate and test a text message-based strategy to streamline care. Our text message-based triage would screen patients before they come to the clinic, allowing patients with no side effects and normal bloodwork to get their infusion without having to wait. To ensure this …
 PRESTA- Promoting Recovery after Stroke with Amantadine
18 years - 99 years
All genders
Phase 2
The research team aims to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial. We will randomize patients post-ischemic or hemorrhagic stroke either to the placebo arm or amantadine. Patients will be on study drug or placebo for 1 month but will …
 Brain Arterio-Venous Metabolomic Profiling
18 years - 99 years
All genders
The research study is being conducted to better understand brain metabolism, i.e. how the brain uses and consumes the various nutrients that are available in the blood. Changes in brain metabolism have been implicated in dementia and psychiatric disorders, as well as short- and long-term outcomes of traumatic brain injury …
 Disrupt CAD III With the Shockwave Coronary IVL System
18 years - 99 years
All genders
The study design is a prospective, multicenter, single-arm, global IDE study to evaluate the safety and effectiveness of the Shockwave Medical Coronary Intravascular Lithotripsy (IVL) System in de novo, calcified, stenotic coronary arteries prior to stenting. Disrupt CAD III is being conducted as a staged pivotal study.
 Strategies in Patients undergoing repeat AF ablation
18 years - 99 years
All genders
Interventional
The aim of the proposed research project is to compare the efficacy of three different ablation strategies in patients with atrial fibrillation (AF) who are undergoing their first repeat catheter ablation for recurrent AF.