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Found 54 neurology trials

A listing of neurology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 HELIOS- A:A Study to Evaluate the Efficacy and Safety of ALN-TTRSC02 in Patients with Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)
18 years - 85 years
All genders
Phase 3
Interventional
The purpose of this study is to evaluate the efficacy and safety of vutrisiran (ALN-TTRSC02) in patients with hereditary transthyretin amyloidosis (hATTR amyloidosis). Participants will receive vutrisiran or the reference comparator patisiran during the Treatment Period.
 Upregulating action semantics to facilitate naming in aphasia
18 years - 99 years
All genders
Phase 1
The goal of this research is to improve the likelihood of aphasia treatment success by activating brain networks that can compensate for language impairment. We will use non-invasive brain stimulation and gesture-priming paradigms to encourage activation of action knowledge (semantics), which we predict will in turn boost verb retrieval. We …
 An Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures
18 years - 99 years
All genders
Interventional
Open label extension trial of CVL-865 in adults with drug-resistant focal onset seizures to learn how well the investigational drug works and how safe it is for long-term epilepsy treatment. Participants will answer questions; undergo physical-neuro exams; vitals; ECG collection; blood draws; urine collection; questions about the study drug; and …
 Safety and Efficacy Study of Ravulizumab in Adults With Generalized Myasthenia Gravis
18 years - 99 years
All genders
Phase 3
Interventional
The primary purpose of this study is to evaluate the safety and efficacy of ravulizumab for the treatment of participants with generalized myasthenia gravis (gMG).
 Safety And Therapeutic Measures Of Transcranial Cathodal Direct Current Stimulation (Tdcs) In Patients With Refractory Focal Epilepsy
9 years - 99 years
All genders
Phase 3
Interventional
The study aims to evaluate the safety, tolerability and efficacy of repeated, daily sessions of transcranial cathodal direct current simulation (tDCS) as administered by the10 STARSTIM (tDCS) device in 10 consecutive days of in-office treatment sessions.
 A Phase 2a Study of TPN-101 in Patients with Progressive Supranuclear Palsy
41 years - 86 years
All genders
Phase 2
Normal 0 false false false EN-US X-NONE X-NONE The research study is being conducted to assess the safety and tolerability of TPN-101 compared to placebo for the treatment of PSP. The study requires the participant and a caregiver to be part of the study.  If you agree to join the …
 MT-3921- Phase 2  Study to Assess the Efficacy and Safety of MT-3921 in Subjects with Acute Traumatic Cervical Spinal Cord Injury
18 years - 70 years
All genders
Phase 2
MT-3921 is an investigational monoclonal antibody therapy for patients with severe (AIS grade A-C) traumatic cervical spinal cord injury (SCIs). This study aims to compare the efficacy of MT-3921 to a placebo with regard to improving patients sensory and motor function and overall quality of life. Additionally this study aims …
 Transforming Research and Clinical Knowledge in Traumatic Brain Injury: Biomarker Project
18 years - 99 years
All genders
The goal of this study is to better understand that which contributes to the long-term recovery of people who have sustained a traumatic brain injury. To better understand an individual’s recovery following a head-injury, we will measure and examine the chemicals released in the brain and blood following the injury. …
 Alzheimers Disease Neuroimaging Initiative 3 (ADNI3)
55 years - 90 years
All genders
Since its launch in 2004, the overarching aim of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI1, ADNI-GO, and ADNI2 studies that have been combined public/private collaborations between academia and industry to determine the …
 Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) Protocol
40 years - 64 years
All genders
The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical/cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's …