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Found 55 neurology trials
A listing of neurology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This is a 5 year study and the purpose is to assess the safety and tolerability of 2 dose levels of PR001A administered via l injection in patients with moderate to severe Parkinson's Disease
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The primary objective of this study is to evaluate the safety and tolerability of single and multiple doses of BIIB094 administered via intrathecal (IT) injection to participants with Parkinson's Disease (PD).
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This study investigates hereditary transthyretin-mediated amyloid polyneuropathy, focusing on evaluating the safety and efficacy of an investigational medication for treating this condition.Who can participate: Adults aged 18 to 82 with Stage 1 or Stage 2 Familial Amyloid Polyneuropathy, a genetic mutation in the TTR gene, and symptoms of neuropathy can …
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The purpose of this study is to better understand the mechanism of action of cladribine tablets. The study will generate hypotheses regarding the impact of cladribine tablet activity in the CNS by assessing the cerebrospinal fluid (CSF) levels of lymphocyte subsets, neuronal injury markers, & soluble immunological markers in study …
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MS is a life-long disease that can clinically manifest at a wide range of ages. Lesions in the white matter of the brain can be found at any age in MS patients. How these lesions may affect functioning of the brain is an area we aim to explore. Although connections …
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SAR443820 is a selective, orally bioavailable, central nervous system (CNS)-penetrant, receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor. The aim of this Phase 2 study is to determine the efficacy, safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of SAR443820 in treating adult participants with amyotrophic lateral sclerosis (ALS).
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ABBV-CLS-7262 is a prodrug that is converted in vivo to the pharmacologically active parent compound A-1684909. A-1684909 is a central nervous system (CNS)-penetrant, eukaryotic translation initiation factor 2B (eIF2B) activator that attenuates the integrated stress response (ISR), a highly conserved cellular mechanism hypothesized to be important in the pathophysiology of …
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This study is an extension of Study 233AS101, a Phase 1/2/3 study evaluating the benefit/risk of BIIB067. This study will evaluate the long-term safety, tolerability, PK, PD, biomarker effects, and efficacy of BIIB067administered to participants with SOD1-ALS.
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The purpose of this study is to evaluate memory, language and cognitive difficulties in patients with ALS. ALS is a neurological disease that affects nerve cells (motor neurons) in the brain and spinal cord. This condition largely affects the muscles however there are some individuals who also experience other neurological …
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The Study is two research trials aimed at preventing Alzheimer’s disease (AD) dementia. One is called AHEAD-3 and the other is called AHEAD-45. AHEAD-3 studies people with intermediate amyloid, while AHEAD-45 studies people with elevated amyloid. Research studies are designed to gain scientific knowledge that may help people in the …
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