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Found 55 neurology trials

A listing of neurology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 A Open-Label Ascending Dose Study to Evaluate the Safety and Effects of PR001A in Patients With Parkinson's Disease
35 years - 80 years
All genders
Phase 1
Interventional
This is a 5 year study and the purpose is to assess the safety and tolerability of 2 dose levels of PR001A administered via l injection in patients with moderate to severe Parkinson's Disease
 A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB094 in Adults With Parkinson's Disease
35 years - 80 years
All genders
Phase 1
Interventional
The primary objective of this study is to evaluate the safety and tolerability of single and multiple doses of BIIB094 administered via intrathecal (IT) injection to participants with Parkinson's Disease (PD).
 An Extension Study to Assess the Long-Term Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB067 Administered to Previously Treated Adults with Amyotrophic Lateral Sclerosis Caused by Superoxide Dismutase 1 Mutation
18 years or above
All genders
Phase 3
Interventional
The primary objective of the study is to evaluate the long-term safety and tolerability of BIIB067 (tofersen) in participants with amyotrophic lateral sclerosis (ALS) and confirmed superoxide dismutase 1 (SOD1) mutation. The secondary objectives are to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), biomarker effects, and efficacy of BIIB067 administered to …
 A Randomized Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
18 years - 82 years
All genders
Phase 3
Interventional
This study investigates hereditary transthyretin-mediated amyloid polyneuropathy, focusing on evaluating the safety and efficacy of an investigational medication for treating this condition.Who can participate: Adults aged 18 to 82 with Stage 1 or Stage 2 Familial Amyloid Polyneuropathy, a genetic mutation in the TTR gene, and symptoms of neuropathy can …
18 years - 100 years
All genders
The purpose of this study is to evaluate memory, language and cognitive difficulties in patients with ALS. ALS is a neurological disease that affects nerve cells (motor neurons) in the brain and spinal cord. This condition largely affects the muscles however there are some individuals who also experience other neurological …
 CLadribine Tablets: Collaborative Study to Evaluate the Impact On Central Nervous System BiomarKers in Multiple Sclerosis
18 years - 65 years
All genders
The purpose of this study is to better understand the mechanism of action of cladribine tablets. The study will generate hypotheses regarding the impact of cladribine tablet activity in the CNS by assessing the cerebrospinal fluid (CSF) levels of lymphocyte subsets, neuronal injury markers, & soluble immunological markers in study …
 A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
55 years - 80 years
All genders
Phase 3
The Study is two research trials aimed at preventing Alzheimer’s disease (AD) dementia. One is called AHEAD-3 and the other is called AHEAD-45. AHEAD-3 studies people with intermediate amyloid, while AHEAD-45 studies people with elevated amyloid. Research studies are designed to gain scientific knowledge that may help people in the …
 Wearable Assessments in the Clinic and Home in PD (WATCH-PD)
30 years - 99 years
All genders
Observational
The purpose of this study is to evaluate disease progression in persons with early Parkinson disease, as assessed by digital and electronic sensor data collection to be correlated with typical clinical assessments.
18 years - 65 years
All genders
MS is a life-long disease that can clinically manifest at a wide range of ages. Lesions in the white matter of the brain can be found at any age in MS patients. How these lesions may affect functioning of the brain is an area we aim to explore. Although connections …
18 years - 80 years
All genders
Phase 2
SAR443820 is a selective, orally bioavailable, central nervous system (CNS)-penetrant, receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor. The aim of this Phase 2 study is to determine the efficacy, safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of SAR443820 in treating adult participants with amyotrophic lateral sclerosis (ALS).
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