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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

CT Guided Ablation of Ganglionated Plexi

CT Guided Ablation of Ganglionated Plexi

18 years - 99 years
All genders
Despite progress made in treating atrial fibrillation with catheter ablation, outcomes remain suboptimal with pulmonary vein isolation alone. Ablation of ganglionated plexi (GP) has been shown to be beneficial in patients with atrial fibrillation although optimal strategies of localization of these regions have yet to be determined. We aim to …
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The Plea Trial(Posterior Wall and Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation)

The Plea Trial(Posterior Wall and Left Atrial Appendage Empiric Electrical Isolation for Non-Paroxysmal Atrial Fibrillation)

18 years - 99 years
All genders
The PLEA trial is designed to test the hypothesis whether posterior wall isolation (PWI) with pulmonary vein isolation (PVI), PWI plus left atrial appendage electrical isolation (LAAEI) with PVI and PWI plus LAAEI plus coronary sinus isolation (CSI) with PVI is superior to the standard approach alone (i.e. PVI alone) …
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UPCC 29420: Phase 1 Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Anti-BCMA Allogeneic CRISPR-Cas9-Engineered T Cells (CTX120) in Subjects With Relapsed or Refractory Multiple Myeloma

99 years or below
All genders
Phase 1
This is a single-arm, open-label, multicenter, Phase 1 study evaluating the safety and efficacy of CTX120 in subjects with relapsed or refractory multiple myeloma.
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UPCC 37420 Phase 2 Study of Belantamab Mafodotin As Pre- and Post- Autologous Stem Cell Transplant Consolidation and Maintenance For Multiple Myeloma

99 years or below
All genders
Phase 2
The research study is being conducted to see if combining an investigational drug, called belantamab mafodotin, with standard-of-care autologous stem cell transplant and maintenance therapy in patients with myeloma can help reduce the amount of myeloma cells that can be detected in patients after transplant. We will also study if …
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Physiologic Response to Non-Invasive Respiratory Support in Obese Patients with Acute Hypoxemic Respiratory Failure from COVID-19

Physiologic Response to Non-Invasive Respiratory Support in Obese Patients with Acute Hypoxemic Respiratory Failure from COVID-19

18 years - 99 years
All genders
This research study only enrolls hospitalized patients at Penn Medicine. The purpose of the study is to assess differences in respiratory and ventilation parameters between HFNC and helmet CPAP in obese patients with COVID-19 AHRF. We will enroll patients admitted to a HUP ICU with COVID-19 who have an obese …
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Duration and Nature of Long-Term Immunosuppression After Neurosurgical Procedure

Duration and Nature of Long-Term Immunosuppression After Neurosurgical Procedure

18 years - 99 years
All genders
Patients greater than 18 years of age undergoing a neurosurgical procedure at Penn Medicine will be approached for enrollment. Currently, this study is open only at the HUP and Penn Presbyterian Medical Center locations.Current research suggests that severe bodily stress caused by surgery may impair the immune system's ability to …
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Understanding the Genetics of Central Centrifugal Cicatricial Alopecia

Understanding the Genetics of Central Centrifugal Cicatricial Alopecia

99 years or below
All genders
The purpose of this study is to characterize gene mutations associated Central Centrifugal Cicatricial Alopecia (CCCA). The Penn Medicine BioBank (PMBB) supports researchers by providing centralized access to a large number of annotated blood and tissue samples. Clinician identified patients with CCCA and appropriate controls will be recruited from the …
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Robotic Nipple Sparing Mastectomy (NSM) Study

Robotic Nipple Sparing Mastectomy (NSM) Study

18 years - 80 years
Female
Phase 3
The goal of this prospective study is to evaluate the safety and effectiveness of the da Vinci Xi Surgical System, instruments, and accessories in Nipple Sparing Mastectomy, otherwise known as NSM procedures.
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A Clinical Trial to Evaluate the Safety and Efficacy of Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor

A Clinical Trial to Evaluate the Safety and Efficacy of Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor

99 years or below
All genders
The Exablate Model 4000 Type-1.0/1.1 Neuro system involves using an advanced, non-invasive technique currently approved by the Food and Drug Administration (FDA) to treat one side of your brain in a procedure called a thalamotomy (lesion the thalamus). This procedure involves performing an ablation (lesion) of an area of the …
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Phase I Study of Tasquinimod Alone and in Combination with Standard Therapy for Relapsed or Refractory Myeloma

Phase I Study of Tasquinimod Alone and in Combination with Standard Therapy for Relapsed or Refractory Myeloma

99 years or below
All genders
Phase 1
The research study is being conducted to understand the effects of tasquinimod, an experimental medication, on patients with myeloma. Eligibile subject have multiple myeloma that has been previously treated and is now in need of additional treatment. Part 1 of this study evaluates tasquinimod alone. Part 2 of this study …
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