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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

An Open-Label Safety and Tolerability Phase 1b Trial of CAN04 A Fully Humanized Anti-IL1RAP Monoclonal Antibody in Combination with Pembrolizumab in Subjects with Solid Tumors Progressing on PD-1/PD-L1 Inhibitor-Containing Regimens

An Open-Label Safety and Tolerability Phase 1b Trial of CAN04 A Fully Humanized Anti-IL1RAP Monoclonal Antibody in Combination with Pembrolizumab in Subjects with Solid Tumors Progressing on PD-1/PD-L1 Inhibitor-Containing Regimens

99 years or below
All genders
Phase 1
This study will consider the safety and effectiveness of a study drug, CAN04, in combination with pembrolizumab, in the treatment of incurable or metastatic non-small-cell lung cancer, head and neck squamous cell carcinoma, urothelial cancer, or malignant melanoma. The study aims to establish a recommended dose of CAN04 in combination …
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Combination Ipatasertib and Atezolizumab to Prevent Recurrence in Triple Negative Breast Cancer

Combination Ipatasertib and Atezolizumab to Prevent Recurrence in Triple Negative Breast Cancer

18 years - 99 years
All genders
Phase 2
The purpose of this study is to determine if a combination of two drugs, Ipatasertib and Atezolizumab, works as a treatment for residual cancer in breast or lymph nodes and have circulating tumor DNA in blood. Eligible subjects will be those with triple negative breast cancer.
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HOPE Trial

HOPE Trial

18 years - 99 years
All genders
HOPE is a randomized clinical trial that will evaluate approaches to reducing pain and opioid use among patients with chronic pain who are receiving maintenance hemodialysis for end-stage renal disease. The hypothesis is that pain coping skills training will be effective at reducing pain and opioid use, and that buprenorphine …
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Cystic Fibrosis Microbiome

Cystic Fibrosis Microbiome

18 years - 99 years
All genders
Among lung transplant recipients who survive to 5 years, half suffer from chronic lung allograft dysfunction (CLAD). This study will evaluate how changes in the lung microbiome may cause CLAD in Cystic Fibrosis patients who have been transplanted. This is a case-control study of Cystic Fibrosis lung transplant recipients to …
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A Trial of Endocrine Response in Women with Invasive Lobular Breast Cancer

A Trial of Endocrine Response in Women with Invasive Lobular Breast Cancer

18 years - 99 years
All genders
Phase 2
To study whether fulvestrant is more effective than anastrozole or tamoxifen in reducing Ki67 in ILC and whether that Ki67 reduction will correlate with alterations in expression of ER and ER-regulated genes. Differential Ki67 effect in this study will serve as a surrogate for outcome of ILC patients on endocrine …
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AGIOS

AGIOS

18 years - 99 years
All genders
Phase 3
Normal 0 false false false EN-US X-NONE X-NONE  This research study is a phase 3, double-blind clinical trial to assess the efficacy of Agios versus placebo in subjects with residual or recurrent Grade 2 oligodendroglioma and astrocytoma with an IDH1 or IDH2 mutation who have undergone surgery as their only …
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UPCC 22420: A Phase 1b Study of Subcutaneous Daratumumab Regimens in Combination with Bispecific T Cell Redirection Antibodies for the Treatment of Subjects with Multiple Myeloma

UPCC 22420: A Phase 1b Study of Subcutaneous Daratumumab Regimens in Combination with Bispecific T Cell Redirection Antibodies for the Treatment of Subjects with Multiple Myeloma

18 years - 99 years
All genders
Phase 1
The purpose of this study is to identify recommended Phase 2 doses (RP2Ds) for each treatment combination (between daratumumab plus talquetamab and teclistamab plus daratumumab) and to characterize the safety of each RP2D for selected treatment combinations. Patients from within the Penn Medicine Cancer Center will be approached as potential participants.
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A study assessing the efficacy and feasibility of virtual cardiac rehabilitation with remotely monitored exercise (VCR)

A study assessing the efficacy and feasibility of virtual cardiac rehabilitation with remotely monitored exercise (VCR)

18 years - 99 years
All genders
This will be an observational study to investigate the feasibility and efficacy of a home-based, tech enabled, remotely supervised, cardiac rehabilitation (CR) program in qualifying American adults who cannot participate in traditional center based rehab.This study aims to investigate the feasibility and effectiveness of Carda Healths remotely administered cardiac rehab …
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Utility of Parametric Response Mapping In Allograft Monitoring After Lung Transplant

Utility of Parametric Response Mapping In Allograft Monitoring After Lung Transplant

18 years - 99 years
All genders
The purpose is to investigate whether parametric response mapping measurements in healthy lung allografts can be used for early detection, prognostication, and phenotyping of CLAD. The target population is bilateral lung transplant recipients who are 6 months post-transplant or later and CLAD free at any of the study institutions. At …
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Treatment In Thoracic Aortic Aneurysm: Surgery versus Surveillance

Treatment In Thoracic Aortic Aneurysm: Surgery versus Surveillance

18 years - 79 years
All genders
This study aims to compare the outcomes of patients undergoing early surgical intervention for ascending aortic aneurysms to those undergoing aneurysm surveillance. Patients with aneurysm diameters between 5.0 and 5.4 cm will be randomized to receive either medical therapy or elective surgery and will be followed annually for 5 years. …
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