Found 1202 All Conditions trials
A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Patients greater than 18 years of age undergoing a neurosurgical procedure at Penn Medicine will be approached for enrollment. Currently, this study is open only at the HUP and Penn Presbyterian Medical Center locations.Current research suggests that severe bodily stress caused by surgery may impair the immune system's ability to …
A Phase 2 Study to Evaluate the Safety and Tolerability of IMR-687 in Subjects with Beta Thalassemia
The purpose of this research study is to: 1) evaluate how well IMR-687 is tolerated in subjects with β-thalassemia and how safe it is, 2) measure the amount of IMR-687 in your blood and 3) evaluate what the drug does to the red blood cells and other blood markers associated …
The goal of this prospective study is to evaluate the safety and effectiveness of the da Vinci Xi Surgical System, instruments, and accessories in Nipple Sparing Mastectomy, otherwise known as NSM procedures.
this study is to evaluate the efficacy of each individual dose of esketamine nasal spray, 56 mg and 84 mg, compared with placebo nasal spray in improving depressive symptoms in participants with TRD, as assessed by the change from baseline in the Montgomery-Asberg Depression Rating Scale (MADRS) total score from …
To collect Tau PET imaging in cognitively normal older African American (AA) adults in the ABCD2 study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the mechanisms and distinctions of age-related cognitive decline and that of Alzheimer's disease. Eligible …
This study will test whether Potassium Nitrate (KNO3), with and without Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR), improves submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF). This study will also test whether the response to supplemental oxygen …
This is a multicenter, exploratory, open-label study to explore the efficacy and/or pharmacodynamic effect, PK, safety, and tolerability of mavacamten in approximately 35 ambulatory participants with symptomatic HFpEF and elevated cTnI and/or elevated NT-proBNP as defined in inclusion/exclusion criteria. The study will include an up to 7-week screening period (with …
In this study, the Investigators at the University of Pennsylvania will assess organ-specific biomarker profiles (proteins and metabolites), in order to better understand biologic processes, the interplay between the heart and extracardiac organs, and their role in human disease, with an emphasis on cardiovascular disease. The study will specifically focus …
The research study is being conducted to understand the effects of tasquinimod, an experimental medication, on patients with myeloma. Eligibile subject have multiple myeloma that has been previously treated and is now in need of additional treatment. Part 1 of this study evaluates tasquinimod alone. Part 2 of this study …
This research study consists of a safety run-in phase and a randomized phase 2 study which include subjects with previously-untreated, metastatic pancreatic adenocarcinoma. In the run-in safety study, the safety of adding two formulations (IV or Oral) of paricalcitol to a standard chemotherapy program of gemcitabine and nab-paclitaxel will be …
