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Found 1253 All Conditions trials
A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
The Effects of Solriamfetol and CBT-I (alone and in combination) on Sleep Continuity Sleepiness Fatigue and Performance in Patients with Insomnia Disorder
PURPOSE: The objective of this project is to test the efficacy of solriamfetol for treating insomnia (alone and in combination with CBT-I). Ultimately, this study will test whether wake extension (regardless of how it is achieved) will consolidate sleep and improve sleep continuity. Patients administered solriamfetol will have significantly greater …
A randomized double-blind placebo controlled 3-arm multicenter phase 3 study to assess the efficacy and safety of ianalumab in patients with active Sjogren's syndrome (NEPTUNUS-2)
This is a 52 wk, randomized, double-blind study to demonstarte the clinical efficacy, safety, and tolerability of ianalumab compared to placebo in patients with active Sjogren's syndrome. Pts will receive a subcutaneous injection of ianalumab/placebo monthly, in addition to salivary flow assessments, blood and urine sampling, PROs, and optional assessments …
A Phase 2 Randomized Open-Label Active Controlled Study Evaluating the Safety and Efficacy of an Oral Weekly Regimen of Islatravir in Combination with Lenacapavir in Virologically Suppressed People with HIV
This is a Phase 2, randomized, open-label, active-controlled, multicenter study to evaluate the safety, efficacy, and PK of ISL + LEN. The target population is virologically suppressed people living with HIV (PWH) who are at least 18 years of age and meet other study inclusion criteria. All participants will be …
Polysomnography Validation of the Sansa Device
The purpose is to validate the Huxley Sansa device and automated scoring algorithm for detecting SDB events compared to the reference standard in-lab PSG. Participants will be recruited from Penn patients age 18+. This is a multi-site, sponsored study where Penn will rely on a central IRB, with enrollment across …
NAC Attack A Phase III Multicenter Randomized Parallel Double Masked Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients with Retinitis Pigmentosa
The objective of the study will be to evaluate the efficacy and safety of oral N-acetylcysteine (NAC) in patients with retinitis pigmentosa (RP). The study is a multi-center, randomized, placebo-controlled study where adult patients diagnosed with RP will be asked to take 1800mg NAC bid or a placebo. Patients will …
Cohort Study of Preclinical Pulmonary Fibrosis
The overall goal of the proposed research is to determine how common genetic variants and environmental risk factors predispose to the development, natural history, and phenotypic heterogeneity of idiopathic interstitial pneumonia (IIP) by establishing and prospectively evaluating a cohort of asymptomatic first-degree relatives of IIP cases.
Pharmacogenetic-guided choice of post-surgery analgesics
1. To determine the feasibility of integrating a PGx panel test in the EMR with a pharmacist PGx e-consult. 2. Determine the fidelity to genotype-guided pharmacotherapy recommendations. 3. To determine if PGx testing will improve the patient self-reported numeric pain scores 4. To determine if PGx testing will reduce MME …
LUX-Dx Insertable Cardiac Monitor Remote Programming and Performance Study (LUX-Dx PERFORM)
The LuxDx Perform study is a prospective, multicenter, single arm post market observational study. Patient indicated to be implanted with the LUX-Dx ICM for one of the ff. reasons cryptogenic stroke, syncope, AF management, post AF ablation or suspected AF will be enrolled in this study. Lux Dx ICM is …
A Phase 2 Evaluation of Tonabersat for Diabetic Macular Edema
This randomized clinical trial will evaluate the effect of tonabersat compared with placebo on central subfield thickness (CST) in eyes with center-involved DME and good visual acuity.
A Prospective Multicenter Non-Blinded Non-Randomized Study of the Relay PRO Thoracic Stent-Graft in Subjects with Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers
The primary safety objective is a composite of the number of Major Adverse Events (MAEs) occurring through 30 days post-procedure compared to the rate in subjects treated with the Relay Thoracic Stent-Graft in the U.S. Pivotal Trial (P110038). The primary effectiveness objective is a composite of the number of effectiveness …
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