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Found 1253 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

HVTN 142: A Phase 1 Randomized Double-Blind Placebo-Controlled Clinical Study to Evaluate the Safety Reactogenicity and Immunogenicity of the HCMV-HIV Vaccine Candidate VIR-1388 in Adult Participants with Overall Good Health and Without HIV

All genders
The purpose of this study is to measure the safety, reactogenicity, and immunogenicity of VIR 1388 in adults in good health without HIV.
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RA Treatment and Common Infections Study

All genders
: This study is a longitudinal, observational, cohort study, recruiting patients from an existing online patient registry (ArthritisPower) and administering monthly online surveys to measure medication exposures and rates of non-hospitalized infection. This study aims to assess the risk of non-hospitalized infection associated with different immunosuppressive treatments, especially glucocorticoids, and …
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NONINTERVENTIONAL EXTENSION STUDY FOR PATIENTS TREATED IN STUDY R5459-RT-1944 WITH REGN5459 OR REGN5458 (BCMA CD3 BISPECIFIC ANTIBODIES) WHO RECEIVE A KIDNEY TRANSPLANT

All genders
The primary objective of the study is to assess adverse events (AEs) and serious adverse events (SAEs) in kidney transplant recipients previously treated with REGN5459 or REGN5458 in the R5459-RT-1944 study. The primary endpoint for this study is the incidence of AEs and SAEs over a 12-month period, starting at …
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An Open-label Long-term Safety and Efficacy Study of Aticaprant as Adjunctive Therapy in Adult and Elderly Participants With Major Depressive Disorder (MDD)

All genders
This is an OL, multicenter, long-term study to evaluate the safety and efficacy of aticaprant 10 mg in combination with an oral antidepressant in adult and elderly participants with MDD and who have had an inadequate response to an SSRI or SNRI in the current depressive episode. Participants will enter …
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Detection and Characterization of Subclinical Atherosclerotic Plaques in High-Risk Populations of Lupus Erythematosus and Dermatomyositis Patients: A Prospective Single-Center Cohort Study

All genders
To determine the burden of subclinical coronary and iliofemoral arterial plaque in 30- to 50-year-old patients with lupus erythematosus (LE) or dermatomyositis (DM) but no clinically evident atherosclerotic cardiovascular disease (ASCVD); and to determine the nature, location, and characteristics of subclinical plaques in these patients. To detect the extent and …
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A PHASE 2 MULTICENTER RANDOMIZED DOUBLE BLIND PLACEBO-CONTROLLED TRIAL TO EVALUATE THE EFFICACY SAFETY AND PHARMACOKINETICS OF REC-4881 IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS (FAP)

All genders
This is a multicenter, randomized, double-blind, placebo-controlled two-part trial in patients with FAP who have previously undergone a colectomy/proctocolectomy using the invesitgational product REC-4881.
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A non-interventional study to assess the long-term safety and efficacy of osilodrostat in patients with endogenous Cushing's syndrome

All genders
To document the long-term safety and tolerability profile of osilodrostat in routine clinical practice over a 3 year follow up period in patients with endogenous Cushing's Syndrome. The study population is male and females 18 years or greater who are being treated with osilodrostat.The primary data source will be the …
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A Randomized Double-Blind Placebo-Controlled Phase 3 Study of AKCEA-APOCIII-LRx Administered Subcutaneously to Patients with Familial Chylomicronemia Syndrome (FCS)

All genders
This is a multi-center, randomized, double-blind, placebo-controlled study of safety and efficacy of ISIS 678354 in patients with FCS. Eligible patients will enter an approximately 4-week Screening Period and an approximately 2-week qualification period. Approximately 60 eligible patients will be randomized 1:1 to Cohort A (50 mg) or Cohort B …
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Developing electrophysiological markers for clinical trials in autistic adults

All genders
The objective is to evaluate a candidate magnetoencephalography (MEG) biomarker, M50, for autism spectrum disorder (ASD) to evaluate group difference between cohorts of adults with ASD vs. typical development as well as stability over a 12-week period. A secondary objective is to determine if the EEG analog of the M50, …
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The Comparison of Different SOC Surgical Approaches in Periodontally Accelerated Osteogenic Orthodontics Treatment with or without the Collagen Matrix

All genders
PURPOSE/DESCRIPTION: The main objective of this study is to clinically and radiographically compare the periodontal phenotype (hard and soft tissue) post orthodontic movement on surgical sites using a corticotomy-facilitated bone augmentation approach. We will compare sites grafted with collagen matrix and allograft bone graft material (test group) to the surgical …
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