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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Dexamethasone in Total Knee Arthroplasty: What Dose Should We Be Giving Patients Intraoperatively?

99 years or below
All genders
Phase 4
PURPOSE/DESCRIPTION: The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.
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NP-G2-044 as Monotherapy and Combination Therapy in Patients With Advanced or Metastatic Solid Tumor Malignancies

99 years or below
All genders
Phase 1
NP-G2-044 Monotherapy Primary Objectives The primary objectives for patients receiving NP-G2-044 monotherapy are the following: - To identify the recommended Phase 2 dose (RP2D) of continuously dosed NP-G2-044 monotherapy (Mono-RP2D) and characterize its safety; and - To assess preliminary signals of NP-G2-044 anti-tumor efficacy when administered as continuously dosed monotherapy. …
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Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients

99 years or below
All genders
Primary Objectives: 1. To establish the prevalence of neuropathic corneal pain in patients with ocular surface discomfort. 2. To assess the overlap of neuropathic corneal pain with dry eye disease in patients in diseases that are currently thought to be mutually exclusive. 3. To establish the prevalence of subtypes of …
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A PHASE IV MULTICENTER OPEN-LABEL STUDY EVALUATING B CELL LEVELS IN INFANTS OF LACTATING WOMEN WITH CIS OR MS RECEIVING OCRELIZUMAB THE SOPRANINO STUDY

99 years or below
All genders
This study will evaluate the pharmacokinetics of ocrelizumab in the breastmilk of lactating women with CIS or MS (in line with the locally approved indications) treated with ocrelizumab, by assessing the concentration of ocrelizumab in mature breastmilk, as well as the corresponding exposure and pharmacodynamic effects (blood B cell levels) …
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Physiology of the Weight Reduced State

99 years or below
All genders
The success of behavioral weight loss is undermined by weight regain. Participants will be assessed at baseline and reassessed if they attain a minimum 7% weight loss (month 0) and undergo follow-up assessments 4 and 12-months later. Changes in physiological measures of metabolism and appetite during weight loss will be …
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Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for greater than 65 Year olds

99 years or below
All genders
Evaluate the long term effectiveness and safety of mitral valve transcatheter edge to edge repair, TERR, campared with surgical repair in patients with primary, degenerative mitral regurgitation.
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A Phase 2 Multicenter Randomized Double-Blind Placebo-Controlled Parallel Group Trial to Investigate the Efficacy and Safety of Daxdilimab Subcutaneous Injection in Reducing Disease Activity in Adult Participants with Moderate-to-Severe Primary Discoid Lupus Erythematosus

99 years or below
All genders
Phase 2
PURPOSE: Phase 2 study to evaluate effect of daxdilimab vs placebo to reduce DLE activity in adults 18-75 yo with DLE. 60 wks 99 pts multiple sites 3 trx grps: placebo; daxdilimab 150 mg; daxdilimab 300 mg. Randomize 1:1:1 sc injections q 4 wks Screening--4 wks; Treatment--48 wks; Follow-Up--8 wks. …
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A Phase 3 Randomized Active-Controlled Open-Label Clinical Study to Evaluate a Switch to Doravirine/Islatravir (DOR/ISL 100 mg/0.25 mg) Once-Daily in Participants With HIV-1 Who Are Virologically Suppressed on Antiretroviral Therapy

99 years or below
All genders
Phase 3
Section 3 HYPOTHESES, OBJECTIVES, AND ENDPOINTS p42-47 in the attached protocol Section 3 HYPOTHESES, OBJECTIVES, AND ENDPOINTS p42-47 in the attached protocol Section 4 STUDY DESIGN p47-56 in the attached protocol Section 3 HYPOTHESES, OBJECTIVES, AND ENDPOINTS p42-47 in the attached protocol Section 4 STUDY DESIGN p47-56 in the attached …
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A DOSE ESCALATION AND PROOF-OF-CONCEPT STUDY OF REGN5459 OR REGN5458 (BCMA CD3 BISPECIFIC ANTIBODIES) FOR DESENSITIZATION OF CHRONIC KIDNEY DISEASE PATIENTS IN NEED OF KIDNEY TRANSPLANTATION WHO ARE HIGHLY SENSITIZED TO HUMAN LEUKOCYTE ANTIGEN

99 years or below
All genders
Phase 2
Please see Section 2 of the full study protocol. Please see Section 4.1 of the full study protocol Please see Section 4.2 of the full study protocol.
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ASH Research Collaborative Data Hub Protocol - A Multi-Center Data Hub of Individuals Living with Hematologic Disease

99 years or below
All genders
The ASH Registry d/b/a the ASH Research Collaborative (ASH RC), is a non-profit organization established by the American Society of Hematology (ASH) in 2018 that aims to improve the lives of those affected by blood diseases by fostering collaborative partnerships to accelerate progress in hematology. The s Data Hub, a …
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