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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Evaluat the Efficacy and Safety of Study Drug Mitapivat in Subjects With Sickle Cell Disease

99 years or below
All genders
Phase 2
Interventional
The purpose of this study is to determine the safety and efficacy of mitapivat in patients with sickle cell disease. Patients will be randomly assigned (like flipping a coin) in a 1:1:1 ratio to receive 50mg mitapivat, 100mg mitapivat or matched placebo for twice-daily oral administration. This means that you …
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Validating a causal model of implementation for CBT

99 years or below
All genders
Observational
The goal of this study is to better understand how therapists make decisions about the treatment they deliver to clients. We will test a causal model of implementation processes in the Philadelphia public mental health system. Our sample will be 200 clinicians and 400 clients across ~30 organizations who will …
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Use of Tecovirimat (TPOXX ) for Treatment of Human Orthopoxvirus Infections

99 years or below
All genders
Interventional
The purpose of this study is to test the use of Tecovirimat (TPOXX ) for Treatment of Human Orthopoxvirus Infections. Tecovirimat (also known as TPOXX or ST-246) is a drug that may help to treat infections caused by pox viruses and reactions to the smallpox vaccine. Eligible Participants: • Have …
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Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial

18 years - 50 years
All genders
Interventional
COSMID is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. The goal of the COSMID trial is to answer the question: For patients with QoL-limiting diverticular disease, is elective colectomy more effective than best medical …
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Assessing Drug Epetraborole in Patients with Mycobacterium avium Complex Lung Disease (MACrO2)

18 years - 99 years
All genders
Interventional
The purpose of this study is to learn about the effects of a study drug, Epetraborole, to assess the efficacy for treating refractory MAC. It will enroll patients over 18 years of age and will include the following: physical exams, CTs, medical history, ECGs, lung function tests, vital signs, safety …
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Stellate Ganglion Blockade During VT Ablation

18 years - 99 years
All genders
Interventional
The purpose of the study is to identify the effects that a “stellate ganglion blockade” has on the electrical and biochemical system of the heart. Eligible participants will be diagnosed ventricular tachycardia and are going to undergo an ablation procedure.
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Kidney Transplantation in Recipients and Donors with HIV: Long Term Follow up Study

18 years - 99 years
All genders
Interventional
The purpose of this study is to study how well patients that receive a kidney from an HIV+ organ donor do over 10 years compared to patients that receive a kidney from an HIV- donor. People 18 years of age and older with end-stage renal disease and HIV, and who …
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The FIRE Trial: Reducing patient memory recall in the burning mouth patient population

The FIRE Trial: Reducing patient memory recall in the burning mouth patient population

18 years - 99 years
All genders
Observational
The purpose of this study is to collect real-time data, such as pain symptoms and exercise habits, to investigate the factors that influence burning mouth symptoms. Participants will be asked to complete questionnaires during the in-person visits and you will receive up to three, random daily notifications from your smartphone …
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Instylla HES Hypervascular Tumor Pivotal Study

22 years - 99 years
All genders
This research study is being conducted to determine if a new investigational device (Instylla Hydrogel Embolic system) can be used to treat tumors which have an extensive blood supply. This means that the tumors have many blood vessels feeding them. This product will be used to close blood vessels supplying …
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Study to evaluate drug BGB-290 with Temozolomide in Recurrent Gliomas with IDH1/2 Mutations

99 years or below
All genders
Phase 1
Interventional
This study is being done to determine how well the study drug, BGB-290, gets into the brain tumor and to confirm if we can continuously and safely give BGB-290 and temozolomide as a combination treatment after surgery. We are testing a dose of temozolomide once a day combined with the …
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