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Found 1202 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A non-interventional study to assess the long-term safety and efficacy of osilodrostat in patients with endogenous Cushing's syndrome

99 years or below
All genders
To document the long-term safety and tolerability profile of osilodrostat in routine clinical practice over a 3 year follow up period in patients with endogenous Cushing's Syndrome. The study population is male and females 18 years or greater who are being treated with osilodrostat.The primary data source will be the …
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A Randomized Double-Blind Placebo-Controlled Phase 3 Study of AKCEA-APOCIII-LRx Administered Subcutaneously to Patients with Familial Chylomicronemia Syndrome (FCS)

99 years or below
All genders
This is a multi-center, randomized, double-blind, placebo-controlled study of safety and efficacy of ISIS 678354 in patients with FCS. Eligible patients will enter an approximately 4-week Screening Period and an approximately 2-week qualification period. Approximately 60 eligible patients will be randomized 1:1 to Cohort A (50 mg) or Cohort B …
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Developing electrophysiological markers for clinical trials in autistic adults

99 years or below
All genders
The objective is to evaluate a candidate magnetoencephalography (MEG) biomarker, M50, for autism spectrum disorder (ASD) to evaluate group difference between cohorts of adults with ASD vs. typical development as well as stability over a 12-week period. A secondary objective is to determine if the EEG analog of the M50, …
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The Comparison of Different SOC Surgical Approaches in Periodontally Accelerated Osteogenic Orthodontics Treatment with or without the Collagen Matrix

99 years or below
All genders
PURPOSE/DESCRIPTION: The main objective of this study is to clinically and radiographically compare the periodontal phenotype (hard and soft tissue) post orthodontic movement on surgical sites using a corticotomy-facilitated bone augmentation approach. We will compare sites grafted with collagen matrix and allograft bone graft material (test group) to the surgical …
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The Effects of Solriamfetol and CBT-I (alone and in combination) on Sleep Continuity Sleepiness Fatigue and Performance in Patients with Insomnia Disorder

99 years or below
All genders
PURPOSE: The objective of this project is to test the efficacy of solriamfetol for treating insomnia (alone and in combination with CBT-I). Ultimately, this study will test whether wake extension (regardless of how it is achieved) will consolidate sleep and improve sleep continuity. Patients administered solriamfetol will have significantly greater …
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A randomized double-blind placebo controlled 3-arm multicenter phase 3 study to assess the efficacy and safety of ianalumab in patients with active Sjogren's syndrome (NEPTUNUS-2)

99 years or below
All genders
This is a 52 wk, randomized, double-blind study to demonstarte the clinical efficacy, safety, and tolerability of ianalumab compared to placebo in patients with active Sjogren's syndrome. Pts will receive a subcutaneous injection of ianalumab/placebo monthly, in addition to salivary flow assessments, blood and urine sampling, PROs, and optional assessments …
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A Phase 2 Randomized Open-Label Active Controlled Study Evaluating the Safety and Efficacy of an Oral Weekly Regimen of Islatravir in Combination with Lenacapavir in Virologically Suppressed People with HIV

99 years or below
All genders
This is a Phase 2, randomized, open-label, active-controlled, multicenter study to evaluate the safety, efficacy, and PK of ISL + LEN. The target population is virologically suppressed people living with HIV (PWH) who are at least 18 years of age and meet other study inclusion criteria. All participants will be …
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Polysomnography Validation of the Sansa Device

99 years or below
All genders
The purpose is to validate the Huxley Sansa device and automated scoring algorithm for detecting SDB events compared to the reference standard in-lab PSG. Participants will be recruited from Penn patients age 18+. This is a multi-site, sponsored study where Penn will rely on a central IRB, with enrollment across …
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NAC Attack A Phase III Multicenter Randomized Parallel Double Masked Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients with Retinitis Pigmentosa

99 years or below
All genders
The objective of the study will be to evaluate the efficacy and safety of oral N-acetylcysteine (NAC) in patients with retinitis pigmentosa (RP). The study is a multi-center, randomized, placebo-controlled study where adult patients diagnosed with RP will be asked to take 1800mg NAC bid or a placebo. Patients will …
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Cohort Study of Preclinical Pulmonary Fibrosis

99 years or below
All genders
The overall goal of the proposed research is to determine how common genetic variants and environmental risk factors predispose to the development, natural history, and phenotypic heterogeneity of idiopathic interstitial pneumonia (IIP) by establishing and prospectively evaluating a cohort of asymptomatic first-degree relatives of IIP cases.
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