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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Clinical Trial to Evaluate Cardiovascular Outcomes in Patients Treated with the Tricuspid Valve Repair System (the “TriClip Device”)

18 years - 99 years
All genders
Interventional
The purpose of this research study is to compare the performance of the investigational (experimental) tricuspid valve repair system plus optimal drug therapy with optimal drug therapy alone. Participants will be randomly assigned to treatment with either the TriClip device (device group) or No TriClip device (control group). Participants will …
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Evaluating Investigational Drug PLN-74809 in Participants with Primary Sclerosing Cholangitis (PSC) and Suspected Liver Fibrosis (INTEGRIS-PSC)

18 years - 75 years
All genders
Phase 2
Interventional
The purpose of this study is to determine the safety and tolerability of an experimental medication PLN-74809 to treat primary Sclerosing Cholangitis (PSC), a rare, long-term liver disease affecting the bile ducts (small tubes) inside and outside the liver. Participants will visit the study center 8 times within 22 weeks. …
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A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety Tolerability and Pharmacokinetics of BIIB105 Administered Intrathecally to Adults With Amyotrophic Lateral Sclerosis With or Without Poly-CAG Expansion in the Ataxin-2 Gene

99 years or below
All genders
This is a first in human, phase 1 trial of BIIB105, which is a novel ASO, in patients with Amyotrophic lateral sclerosis (ALS) and ALS associated with ataxin-2 (ATXN2) poly-CAG expansion (polyQ-ALS). BIIB105 will be administered via fluoro-guided LP up to 5 times over approximately 3 months. Subjects will undergo …
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Evaluating Study Drug Danicopan (ALXN2040) in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)

70 years - 99 years
All genders
Phase 2
Interventional
This study will test danicopan, a new drug that is being developed by Alexion to slow down progression of GA. The goals of this study are as follows: • To find out whether danicopan can slow the rate of GA disease progression, and in turn slow the loss of visual …
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Study to Evaluate New Drug AGN-151586 for the Treatment of Glabellar Lines

18 years - 99 years
All genders
Phase 3
Interventional
The purpose of this study is to test a new drug called AGN-151586 as a treatments for patients with moderate to severe frown lines between the eyebrows (glabellar) over a period of 18 weeks. Procedures include Vital signs, Physical Exam, Medical History, Blood and Urine tests, ECG, Neurological exam and …
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A Phase 2 Open-label Study to Evaluate the Safety and Efficacy of VGT-309 a Tumor-Targeted Activatable Fluorescent Imaging Agent to Identify Cancer in Subjects Undergoing Lung Cancer Surgery

99 years or below
All genders
Phase 2
To evaluate the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of VGT-309 to detect cancer utilizing near-infrared (NIR) fluorescence and histopathology results. 1. Sensitivity: defined as the probability that the tissue fluoresces when it is cancer, as confirmed by histology (TP/(TP+FN)) 2. Specificity: defined as the …
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Evaluating an Investigative Drug Letermovir (Prevymis) in Adults with Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV)

40 years - 99 years
All genders
Interventional
The purpose of this study is to test letermovir when given to people who have both well-controlled HIV infection and asymptomatic CMV infection. This study will also gather data on the effectiveness of letermovir to reduce inflammation when compared to no anti-CMV study treatment. In addition, the study will collect …
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SPOTLITE: Study of Surgical Interventions in Complex Fistulizing Conditions (CPF-CD CD-RVF CCF)

18 years - 99 years
All genders
Observational
An observational study that aims to collect data over time on the effect of surgery on patient's with a complex fistulizing condition such as: • complex perianal fistula with Crohn’s Disease (CPF-CD) • rectovaginal fistula with Crohn’s Disease (CD-RVF), or • complex cryptoglandular fistulas (CCF). The study will follow patients …
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Pre-op CBT to Reduce the Risk for Development of Chronic Post-surgical Pain in Patients Undergoing Total Knee Arthroplasty

Pre-op CBT to Reduce the Risk for Development of Chronic Post-surgical Pain in Patients Undergoing Total Knee Arthroplasty

21 years - 99 years
All genders
    This research study is being conducted to evaluate a treatment approach that may make the pain or discomfort experienced following surgery less severe and decrease the length of time this pain or discomfort will last. Stress, pain and opioid medication use prior to surgery can make post-operative pain …
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PREPARE: A Pragmatic Randomized trial Evaluating Pre-operative Alcohol skin solutions in FRactured Extremities

18 years - 99 years
All genders
Observational
The purpose of this study is to determine which pre-operative solution, iodine-povacrylex or chlorhexidine gluconate, is better at lowering the risk of infection and complications requiring additional surgery in patients with fractures.
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