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Found 1202 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Pilot Early Feasibility Study of Safety and Effectiveness of Telemetric Intracranial Pressure Monitoring in Spaceflight Participants Before During and After Commercial Orbital Spaceflight

99 years or below
All genders
The participant (astronaut) will enroll in this study because he/she is scheduled for a spaceflight that puts him at risk for developing SANS. This study will monitor ICP and craniospinal compliance by a Miethke M.scio telemetric ICP device. The astronaut will go through centrifuge testing prior to the spaceflight. UPenn …
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UPCC 16122 A Phase II Multicentre Open-Label Study to Assess the Efficacy and Safety of Olaparib Monotherapy and Olaparib Plus Durvalumab Combination as Neoadjuvant Therapy in Patients with BRCA Mutations and Early Stage HER2-Negative Breast Cancer (OlympiaN)

99 years or below
All genders
This study to learn more about olaparib and olaparib plus durvalumab combination therapy and also to better understand the studied disease, breast cancer, and associated health problems.
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UPCC 04423: Expanded Access Program for belantamab mafodotin in Patients with Relapsed/Refractory Multiple Myeloma who are Refractory to a Proteasome Inhibitor and an Immunomodulatory Agent and an Anti-CD38 Antibody

99 years or below
All genders
Compassionate use access to belantamab mafodotin (GSK2857916) for eligible participants with refractory/relapsing multiple myeloma. We would like to rely on WCG as the IRB of record for this study.
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THE COMPARATIVE EFFECTIVENESS OF 7 VERSUS 21 HOME-DELIVERED MEDICALLY TAILORED MEALS TO IMPROVE MALNUTRITION RISK IN MALNOURISHED PATIENTS WITH HEART FAILURE: A RANDOM ORDER CROSSOVER FEEDING TRIAL (MEDIMEALS)

99 years or below
All genders
The objectives of the random order crossover design study are to compare the effectiveness of 7- versus 21- meals/week on the primary outcome of malnutrition risk score and secondary outcomes of unplanned emergency department visits or hospital readmissions and on diet quality. The primary outcome is the malnutrition risk score …
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A Multicenter Randomized Controlled Trial of Surveillance vs. Endoscopic Therapy for Barretts Esophagus with Low-grade Dysplasia

99 years or below
All genders
To compare the effectiveness of two approaches for the management of BE and LGD, endoscopic surveillance and endoscopic eradication therapy (EET), using accepted clinical endpoints of neoplastic progression [high-grade dysplasia (HGD)/mucosal esophageal adenocarcinoma (EAC)/invasive EAC] as determined by a blinded central adjudication committee
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A Phase 3 Open-label Clinical Study of Doravirine/Islatravir (DOR/ISL [100 mg/0.25 mg]) Once Daily for the Treatment of HIV-1 Infection in Participants Who Previously Received DOR/ISL (100 mg/0.75 mg) QD in a Phase 3 Clinical Study

99 years or below
All genders
Phase 3
Section 3 HYPOTHESES, OBJECTIVES, AND ENDPOINTS page 35 in the attached protocol. Section 4 STUDY DESIGN page 36-39 in the attached protocol. Section 4 STUDY DESIGN page 36-39 in the attached protocol.
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Lung Transplant Outcomes Group: Tacrolimus

99 years or below
All genders
Using a pilot cohort, we hope to estimate tac PK parameters and conduct simulation studies to support design of a multicenter study to develop and validate a robust post-lung transplant tac population pharmacokinetic (popPK) model. The primary outcome will be the area under the concentration-time curve (AUC), which will provide …
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A prospective multi-center open label and single arm clinical investigation to evaluate the safety and efficacy of using the Zoom Reperfusion System in thrombectomy procedures to treat acute ischemic stroke patients

99 years or below
All genders
REFER TO PROTOCOL
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Dexamethasone in Total Knee Arthroplasty: What Dose Should We Be Giving Patients Intraoperatively?

99 years or below
All genders
Phase 4
PURPOSE/DESCRIPTION: The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.
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NP-G2-044 as Monotherapy and Combination Therapy in Patients With Advanced or Metastatic Solid Tumor Malignancies

99 years or below
All genders
Phase 1
NP-G2-044 Monotherapy Primary Objectives The primary objectives for patients receiving NP-G2-044 monotherapy are the following: - To identify the recommended Phase 2 dose (RP2D) of continuously dosed NP-G2-044 monotherapy (Mono-RP2D) and characterize its safety; and - To assess preliminary signals of NP-G2-044 anti-tumor efficacy when administered as continuously dosed monotherapy. …
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