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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Phase I Trial of Programmed Allogeneic CRISPR-edited T cells (PACE) Gene Edited to Eliminate Endogenous TCR HLA-class I and HLA-class II and Engineered to Express anti-CD19 Chimeric Antigen Receptor (PACE CART19) in Patients with Relapsed Or Refractory CD19+ Leukemia and Lymphoma

Phase I Trial of Programmed Allogeneic CRISPR-edited T cells (PACE) Gene Edited to Eliminate Endogenous TCR HLA-class I and HLA-class II and Engineered to Express anti-CD19 Chimeric Antigen Receptor (PACE CART19) in Patients with Relapsed Or Refractory CD19+ Leukemia and Lymphoma

18 years - 99 years
All genders
Phase 1
Interventional
This research study is being conducted to evaluate an experimental drug called PACE CART19 in patients with leukemia or lymphoma. PACE CART19 consists of cells from a healthy donor that are genetically modified and designed to target your cancer.
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Diet Interventions in Psoriatic Arthritis

Diet Interventions in Psoriatic Arthritis

18 years - 99 years
All genders
Observational
In this randomized controlled pilot trial, we will test whether a Mediterranean diet (focused on healthy food intake) or a low calorie/low fat (LC/LF) diet (aiming for weight reduction) improves disease outcomes compared to no dietary intervention among patients with PsA.
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A study to evaluate the impact of cariprazine (1.5mg) on cocaine use in OUD-CocUD patients on buprenorphine-naloxone.

A study to evaluate the impact of cariprazine (1.5mg) on cocaine use in OUD-CocUD patients on buprenorphine-naloxone.

18 years - 65 years
All genders
Phase 2
The research study is being conducted to understand whether the medication, cariprazine, affects drug use, and brain and behavioral responses in people with opioid and cocaine use disorder already being treated with the medication buprenorphine-naloxone (brand names: Suboxone, Zubsolv, Bunavail). Cariprazine (VRAYLAR ) is FDA-approved for the treatment of certain …
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SPLASH: Study Evaluating Metastatic Castrate Resistant Prostate Cancer Treatment Using 177Lu-PNT2002 PSMA Therapy After Second-line Hormonal Treatment

SPLASH: Study Evaluating Metastatic Castrate Resistant Prostate Cancer Treatment Using 177Lu-PNT2002 PSMA Therapy After Second-line Hormonal Treatment

18 years - 99 years
Male
Phase 3
Interventional
This is a research study for those with metastatic castration-resistant prostate cancer (mCRPC) that has progressed following treatment with prior therapy and cannot receive or refuse to receive chemotherapy. The purpose of this research study is to learn about the safety and effectiveness of 177Lu PNT2002, an investigational agent being …
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Drug-Induced Sleep Endoscopy (DISE): Phenotyping Obstruction Patterns

Drug-Induced Sleep Endoscopy (DISE): Phenotyping Obstruction Patterns

18 years - 99 years
All genders
Interventional
The research study is being done to better understand how and why the airway collapses during sleep. We would like to find out what types of things (for example, air flow, air pressure, or face shape) affect if someone’s throat closes up during sleep and how well they do after …
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Harnessing Hormonal Variation to Probe Neural Mechanisms of OCD and Symptom Reduction by EX/RP

Harnessing Hormonal Variation to Probe Neural Mechanisms of OCD and Symptom Reduction by EX/RP

18 years - 45 years
All genders
Studies show that hormones affect the brain’s fear extinction network, which is relevant for therapy involving exposure and ritual prevention (EX/RP), a first-line treatment for obsessive compulsive disorder (OCD). This study will examine the effect of delivering EX/RP to women during different phases in their menstrual cycle to determine the effects of hormones on the …
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Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis

Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis

40 years - 99 years
All genders
This study is looking to see if inhaled treprostinil helps patients with IPF improve their pulmonary function tests. Patients will randomized to either placebo or inhaled treprostinil and will also undergo the following throughout the study: PFTs, physical exams, EKGs, HRCT, questionnaires, vital signs, lab tests
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Observational Characterization of the Treatment Course of Patients With Thyroid Eye Disease

Observational Characterization of the Treatment Course of Patients With Thyroid Eye Disease

18 years - 99 years
All genders
This study will: • Evaluate standard-of-care (SOC) treatment for TED in a real-world setting • Evaluate effectiveness of the treatment in terms of protrusion of the eyeball (proptosis) • Show if the SOC treatment has any effect on eye anatomy and function and fi the appearance of the subject’s eyes …
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A Study to Evaluate Patients with TransthyretinMediated Amyloid Cardiomyopathy (ATTR CM)

A Study to Evaluate Patients with TransthyretinMediated Amyloid Cardiomyopathy (ATTR CM)

18 years - 90 years
All genders
Phase 3
Interventional
This study is for those diagnosed with transthyretin-mediated amyloid cardiomyopathy which is a disease caused by change in a protein called transthyretin (TTR). This change can either be sporadic which is known as wild-type (wtATTR-CM) or due to a mutation of the TTR gene which is hereditary (hATTR-CM). In both …
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Maintenance Therapy in Patients with Multiple Myeloma (MM) Using Minimal Residual Disease (DRAMMATIC Study)

Maintenance Therapy in Patients with Multiple Myeloma (MM) Using Minimal Residual Disease (DRAMMATIC Study)

17 years - 75 years
All genders
Interventional
This study will examine whether adding the drug daratumumab/rHuPH20 to the usual maintenance treatment with lenalidomide after stem cell transplant help multiple myeloma patients survive longer. For patients who do not have minimum residual disease [MRD-negative], this study is also trying to determine if maintenance therapy should be stopped after …
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