Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

To identify reliable markers of LRRK2 activity in human CSF.

30 years - 99 years

Accepts healthy volunteer

All genders

The purpose of this research study is to evaluate new tests for Parkinson's disease (PD) that may help in developing better treatments.

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Edwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy using a Novel Device

18 years - 99 years

All genders

Interventional

The research study is being conducted to determine the safety and effectiveness of an investigational device, called the Edwards EVOQUE Replacement system (EVOQUE system) with Optimal Medical Therapy (OMT) compared to OMT alone for the treatment of tricuspid valve regurgitation (TR)

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STRIDE Study : The Effects of semaglutide on functional capacity in pith type 2 diabetes and peripheral arterial disease

18 years - 99 years

All genders

Phase 3

This is a 52 week, randomized, double-blind, placebo-controlled trial comparing semaglutide 1 mg versus placebo both added to standard of care and administered once weekly in subjects with Type 2 Diabetes Mellitus with Intermittent Claudication.

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A071701 Genomically-Guided Treatment Trial in Brain Metastases

18 years - 99 years

All genders

Interventional

This phase II trial studies how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain. Several genes have been found to be altered or mutated in brain metastases such as NTRK, ROS1, CDK or PI3K. Medications that target these genes such …

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A Randomized Study to Compare Efficacy Safety and Tolerability of Macitentan 75mg Versus Macitentan 10mg in Patients with Pulmonary Arterial Hypertension Followed by an Open-label Treatment Period with Macitentan 75mg

18 years - 75 years

All genders

Phase 3

TThe research study is being conducted to compare macitentan 75 mg with the approved macitentan 10 mg to see if it is well tolerated, safe and useful for treating patients with pulmonary arterial hypertension (PAH).

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GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients (LuTK02)

18 years - 99 years

All genders

This trial is to evaluate the safety and efficacy of adding GMCI to standard of care in patients with stage III/IV NSCLC that are not responding to a first line immune checkpoint inhibitor (ICI).

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A Randomized Double-Blind Placebo-Controlled Active Comparator Phase 2/3 Study of Tucatinib in Combination With Trastuzumab Ramucirumab and Paclitaxel in Subjects With Previously Treated Locally-Advanced Unresectable or Metastatic HER2+ Gastric or Gastroesophageal Junction Adenocarcinoma (GEC)

19 years - 99 years

All genders

This study is being done to see if tucatinib with trastuzumab, ramucirumab and paclitaxel works better than ramucirumab and paclitaxel to treat HER2-positive (HER2+) cancer of the gut (stomach or gastroesophageal cancer). This study will also look at what side effects happen when participants take this combination of drugs

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Study of Surufatinib in Combination with Tislelizumab in Subjects With Advanced Solid Tumors

18 years - 99 years

All genders

Phase 1

Interventional

study of surufatinib in combination with tislelizumab will evaluate the safety, and tolerability in patients with advanced solid tumors.

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Study Of Avb-S6-500 In Combination With Cabozantinib Versus Cabozantinib Alone In Patients With Advanced Clear Cell Renal Cell Carcinoma Who Have Received Front-Line Treatment

18 years - 99 years

All genders

Phase 2

This is a Phase 1b/2 study of AVB-S6-500 designed to evaluate the safety and efficacy of AVB-S6-500 in combination with cabozantinib in subjects with advanced clear cell renal cell carcinoma (ccRCC) that have received front-line treatment.

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Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU: A Randomized Trial

99 years or below

All genders

The objective of this study is to determine whether apneic oxygenation (nasal cannula 6L/min with FiO2 100%) delivered during laryngoscopy and tracheal intubation, compared with no respiratory support or oxygenation during laryngoscopy and tracheal intubation attempts (standard of care), reduces the magnitude of oxygen desaturation during tracheal intubation encounters in …

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Found 1243 All Conditions trials

To identify reliable markers of LRRK2 activity in human CSF.

Edwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy using a Novel Device

STRIDE Study : The Effects of semaglutide on functional capacity in pith type 2 diabetes and peripheral arterial disease

A071701 Genomically-Guided Treatment Trial in Brain Metastases

A Randomized Study to Compare Efficacy Safety and Tolerability of Macitentan 75mg Versus Macitentan 10mg in Patients with Pulmonary Arterial Hypertension Followed by an Open-label Treatment Period with Macitentan 75mg

GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients (LuTK02)

A Randomized Double-Blind Placebo-Controlled Active Comparator Phase 2/3 Study of Tucatinib in Combination With Trastuzumab Ramucirumab and Paclitaxel in Subjects With Previously Treated Locally-Advanced Unresectable or Metastatic HER2+ Gastric or Gastroesophageal Junction Adenocarcinoma (GEC)

Study of Surufatinib in Combination with Tislelizumab in Subjects With Advanced Solid Tumors

Study Of Avb-S6-500 In Combination With Cabozantinib Versus Cabozantinib Alone In Patients With Advanced Clear Cell Renal Cell Carcinoma Who Have Received Front-Line Treatment

Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU: A Randomized Trial