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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Assessment of the CARILLON Mitral Contour System in Treating Functional Mitral Regurgitation Associated with Heart Failure

99 years or below
All genders
Prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the CARILLON Mitral Contour System in treating functional mitral regurgitation associated with heart failure.
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Transseptal vs. Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli Multi-center comparative effectiveness randomized clinical trial to assess a transeptal approach to left ventricular ablation compared to a retrograd aortic aproach to prevent cerebral emboli and neurocognitive decline in adults with ventricular tacht=ycardia (VT) and /or premature ventricular contractions (PVCs)

99 years or below
All genders
Both transseptal and retrograde aortic approaches are routinely utilized in pediatric and adult cardiac electrophysiology and cardiac catheterization laboratories in the United States and have been in clinical practice for decades to treat multiple types of left atrial and ventricular arrhythmias. As either approach can be used to perform catheter …
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A Phase 3 Open-Label Multi-Center Trial to Evaluate the Long- Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults with Isolated Cervical Dystonia (ASPEN-OLS)

99 years or below
All genders
Phase 3
This is a Phase 3, open-label, multi-center trial to evaluate the long-term safety, efficacy, and immunogenicity of up to four continuous treatment cycles of daxibotulinumtoxinA (DAXI) for injection at doses of 125 U, 200 U, 250 U, or 300 U in adults with isolated cervical dystonia (CD). Approximately 290 adult …
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A Global Phase 2 Randomized Double-Blind Placebo-Controlled Dose-Ranging Study of BMS-986177 an Oral Factor XIa Inhibitor for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

99 years or below
All genders
Phase 2
See full protocol for details.
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A Randomized Sham Surgery Controlled Double-blinded Multi-center Phase 2 Clinical Trial Evaluating the Efficacy and Safety of VY-AADC02 in Moderate to Advanced Parkinsons Disease with Motor Fluctuations

99 years or below
All genders
Phase 2
The main purpose of this study is to test the safety and efficacy (how well it works) of an experimental intervention called VY-AADC02 on the severity of PD. VY-AADC02 involves placing a gene in the brain that programs brain cells to produce an enzyme (protein) called AADC (aromatic amino acid …
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A multicenter randomized controlled phase 2 study: Efficacy and safety of I-131-1095 radiotherapy in combination with enzalutamide in metastatic castration-resistant prostate cancer (mCRPC) patients who are 18F-DCFPyL prostate specific membrane antigen (PSMA)-avid chemotherapy-na ve and progressed on abiraterone (ARROW)

99 years or below
All genders
Phase 2
A multicenter, open label, randomized phase 2 study of I-131-1095 radiotherapy (less than or equal to 100 mCi/dose) every 8 weeks for up to 4 doses in combination with enzalutamide compared to enzalutamide alone in patients with progressive mCRPC. Patients must have documented progression on abiraterone and be indicated for …
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Post-Market Evaluation of the Accuracy and User Satisfaction of the BD Intelliport Medication Management System in a High Volume Single academic Site

99 years or below
All genders
This clinical study will consist of a post-market evaluation of the accuracy and user satisfaction of the System in a high volume single academic site. The study will compare overall anesthesia provider satisfaction with the System and the current approach for delivering and charting IV bolus medications. A small cohort …
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Infection Control Exposures Microbiome and MDRO Transmission Study (ICEMAN)

99 years or below
All genders
We propose a study in a hospital setting with high rates of multi-drug resistant organisms (MDROs) and healthcare-associated infections (HAIs), the intensive care unit (ICU), to examine the impact of patient exposures on the environmental microbiome and transmission of MDROs to the environment. This study will involve: a) longitudinal sampling …
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A Phase 2 Study for the Evaluation of Safety and Efficacy of Humacyte's Human Acellular Vessel for Vascular Replacement or Reconstruction in Patients with Life or Limb-threatening Vascular Trauma

A Phase 2 Study for the Evaluation of Safety and Efficacy of Humacyte's Human Acellular Vessel for Vascular Replacement or Reconstruction in Patients with Life or Limb-threatening Vascular Trauma

99 years or below
All genders
Phase 2
This is a prospective, multicenter, multi-cohort (limb and torso), non-randomized study designed to evaluate the safety and tolerability of the Humacyte HAV in vascular trauma patients undergoing surgery for vascular replacement or reconstruction. The University of Pennsylvania will participate as a site by enrolling subjects between the ages of 18 …
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A Multiple-Site Phase 1/2 Safety and Efficacy Trial of a Recombinant Adeno-associated Virus Vector Expressing CNGB3 (rAAV2tYF-PR1.7-hCNGB3) in Patients with Congenital Achromatopsia Caused by Mutations in the CNGB3 Gene

A Multiple-Site Phase 1/2 Safety and Efficacy Trial of a Recombinant Adeno-associated Virus Vector Expressing CNGB3 (rAAV2tYF-PR1.7-hCNGB3) in Patients with Congenital Achromatopsia Caused by Mutations in the CNGB3 Gene

99 years or below
All genders
Phase 2
Achromatopsia is an inherited retinal disorder characterized by markedly reduced visual acuity, nystagmus, photoaversion (intolerance to bright light), a small central scotoma, eccentric viewing, and complete or severe loss of color discrimination. The genetic mutations of the disease can be established in the majority of individuals. Approximately 50% are caused …
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