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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A pilot study evaluating in vivo PARP-1 expression with18F-FluorThanatrace positron emission tomography (PET/CT) in glioblastoma

99 years or below
All genders
Phase 1
This is a companion imaging study that plans to enroll adult subjects with recurrent glioblastoma that meet the eligibility criteria for a treatment trial entitled A phase II study evaluating the efficacy and safety of niraparib and tumor-treating fields in recurrent glioblastoma, IRB 832694/UPCC 03319. IRB 832694 is a study …
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A Phase 1 Open-Label Safety Pharmacokinetic and Preliminary Efficacy Study of STRO-002 An Anti-Folate Receptor alpha Antibody- Drug Conjugate (ADC) In Patients with Advanced Epithelial Ovarian Cancer (including Fallopian Tube or Primary Peritoneal Cancers) and Endometrial Cancers

99 years or below
All genders
Phase 1
This study has two parts: Part 1 (dose escalation) and Part 2 (dose expansion). The purpose of Part 1 is to determine: What effects, good and/or bad, STRO-002 has on subjects and their disease The highest dose of STRO-002 that can be safely given to subjects using a pre-defined starting …
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Effects of Mu-opiate receptor engagement on the persistence of HIV-associated activation and viral reservoirs in individuals receiving medication assisted treatment for opioid use disorder

99 years or below
All genders
Both HIV infection and exposure to opioids, including intravenous heroin in people who inject drugs (PWIDs), are associated with systemic immune activation due to, at least partially, dysbiosis and increased microbial translocation from the gut. Medication-assisted treatment (MAT) approaches based on the administration of Opioid Receptor (MOR) agonists (e.g. methadone) …
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Does vaginal delivery of combined hormonal contraception affect the risk of metabolic syndrome in overweight/obese women with PCOS?

99 years or below
All genders
This research study is being conducted to determine if there is an effect on the development of Metabolic Syndrome (MetS) in women with PCOS when using NuvaRing. This study will recruit 40 women between the ages of 18-40, with a diagnosis of PCOS, NO diagnosis of MetS, and a BMI …
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Pilot Study of EsoCheck Compared to Biopsies and Brush Cytology During Endoscopy for Evaluation of Eosinophilic Esophagitis

99 years or below
All genders
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that can lead to remodeling and stricture formation. To assess response to therapy, upper endoscopy (EGD) with biopsies is performed. This can lead to multiple EGDs, which are invasive and costly. There is currently a substantial unmet need for …
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A Phase II Study of the Anti-GITR Agonist INCAGN01876 and the PD-1 Inhibitor INCMGA00012 in Combination with Stereotactic Radiosurgery in Recurrent Glioblastoma

99 years or below
All genders
Phase 2
The following protocol is a phase II study of the combination of the GITR agonist monoclonal antibody INCAGN01876, the anti-PD1 monoclonal antibody INCMGA00012, and SRS for recurrent GBM. We hypothesize that the proposed regimen will be safe and stimulate a robust anti-tumor immune response and result in improved tumor responses. …
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Investigating Potential of Personalized Biomarkers in Redefining Treatment Response in Patients with Glioblastoma using Multiparametric MRI and Liquid Biopsy

99 years or below
All genders
This study aims to investigate 30 patients with a diagnosis of Glioblastoma to develop a decision support system by incorporating advanced MR imaging, liquid biopsy, and MGMT promoter status to determine with higher accuracy whether tumor changes are true progression or pseudo progression. Analysis of these results will hopefully have …
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Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV

Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV

18 years - 99 years
All genders
Phase 3
The research study is being conducted to examine the effects of personalized smoking cessation medication treatment in order to help people with HIV/AIDS to quit smoking. During the study, participants will take either varenicline (brand name Chantix®) or use the nicotine patch, and they will receive smoking cessation therapy with …
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Aging Chronobiome Study

Aging Chronobiome Study (Acronym-1)

18 years - 75 years
Accepts healthy volunteer
All genders
We invite you to participate in a research study where we explore how young and old people differ in their behavioral and biological rhythms. The main criteria to qualify as a research subject are: 1.) you are apparent healthy, 2.) you own a smartphone and 3.) you are either between …
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Phase 2 Trial of AGEN2034 (anti-PD-1) as a Monotherapy of Combination Therapy with AGEN1884 (anti-CTLA4) or with Placebo in Women with Recurrent Cervical Cancer (Second Line) - RaPiDS

Phase 2 Trial of AGEN2034 (anti-PD-1) as a Monotherapy of Combination Therapy with AGEN1884 (anti-CTLA4) or with Placebo in Women with Recurrent Cervical Cancer (Second Line) - RaPiDS

99 years or below
All genders
Phase 2
The research study is being conducted to study the PD-1 antibody, AGEN2034 alone, or in combination with the CTLA-4 antibody, AGEN1884, in women with recurrent cervical cancer. Subjects will be asked to complete the following research procedures: 12 lead electrocardiogram (ECG) and evaluation of heart function (to determine heart health). …
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