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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Intratumoral Gene Mediated Cytotoxic Immunotherapy (GMCI) For Resectable Non-Small Cell Lung Cancer

Intratumoral Gene Mediated Cytotoxic Immunotherapy (GMCI) For Resectable Non-Small Cell Lung Cancer

99 years or below
All genders
Phase 1
Surgery is the best treatment for patients with Stage I or II lung cancer; however, nearly 60% of patients have recurrence. Additional immunotherapeutic agents given before surgery may be greatly reduce recurrence. This is a Standard Phase I, 3+3 dose escalation trial designed to evaluate the safety and toxicity of …
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Pragmatic Phase Iii Randomized Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial

Pragmatic Phase Iii Randomized Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial

99 years or below
All genders
Phase 3
This is a pragmatic randomized clinical trial in which patients with locally advanced breast cancer will be randomized to either proton or photon therapy and followed longitudinally for cardiovascular morbidity and mortality, health-related quality of life (HRQOL), and cancer control outcomes. We hypothesize that proton therapy, as part of multi-modality …
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KCP-330-020

KCP-330-020

18 years - 99 years
All genders
Phase 2
The purpose of this study is to see if the investigational drug, selinexor, has any effects in eligible participants with advanced unresectable dedifferentiated liposarcoma (DDLS). Selinexor will be given at a fixed oral dose of 60mg or placebo twice weekly on Days 1 and 3 during Weeks 1-6 of each …
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Open-Labeled Trial Of Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors

Open-Labeled Trial Of Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors

99 years or below
All genders
Phase 2
Since 2006, there has been a 50% increase in the number of adults added to the heart transplant waitlist in the US. Yet the persistent organ donor shortage has led to only a 25% increase in the number of transplants, and a 25% increase in the number of patients removed …
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Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure

Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure

99 years or below
All genders
Randomized (flip of the coin 50/50) study of heart failure (HF) patients with moderate aortic valve stenosis (narrowing) will be either treated with a transcatheter valve replacement (TAVR) or continue with medical management. Subjects will be followed for 2 years. We will collect information regarding death and major events such …
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TARGET-PBC: A 5-year Longitudinal Observational Study of Patients with Primary Biliary Cholangitis

TARGET-PBC: A 5-year Longitudinal Observational Study of Patients with Primary Biliary Cholangitis

18 years - 80 years
All genders
You are being asked to be in this research study because you have PBC (primary biliary cholangitis) which is an uncommon chronic cholestatic liver disease characterized by progressive inflammation and destruction of the interlobular bile ducts, ultimately leading to the development of biliary cirrhosis. 
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A Pilot Study of Diffusion Weighted MRI to Assess Esophageal Tumor Response to Neoadjuvant Chemoradiation

A Pilot Study of Diffusion Weighted MRI to Assess Esophageal Tumor Response to Neoadjuvant Chemoradiation

99 years or below
All genders
Phase 1
The purpose of this study is to determine if a particular Magnetic Resonance Imaging (MRI) called Diffusion Weighted (dwMRI)) will detect changes in your tumor before and during treatment with chemotherapy and radiation for esophageal cancer. We used the dwMRI because it has been used in other types of cancers …
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Alzheimers Disease Neuroimaging Initiative 3 (ADNI3)

Alzheimers Disease Neuroimaging Initiative 3 (ADNI3)

55 years - 90 years
All genders
Since its launch in 2004, the overarching aim of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI1, ADNI-GO, and ADNI2 studies that have been combined public/private collaborations between academia and industry to determine the …
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PTSD Treatment Study

PTSD Treatment Study

18 years - 45 years
Female
Phase 2
Have you experienced a traumatic event that affected your life significantly? You may be eligible to participate in a study conducted by the Center for the Treatment and Study of Anxiety at the University of Pennsylvania.In this study we will investigate the influence of gonadal hormones on fear acquisition and extinction …
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Evaluation of the GORE TAG Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta

Evaluation of the GORE TAG Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta

99 years or below
All genders
The purpose of this study is to evaluate the safety and effectiveness of the study device, which is an endoprosthesis (stent) that is used to treat various lesions of the aortic arch and descending thoracic aorta. Lesions might include aortic aneurysm (weakened area of the aorta), dissection (tear in the …
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