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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Study with Safety Run-in to Evaluate the Safety Tolerability and Preliminary Efficacy of FF-10832 Monotherapy or in Combination with Pembrolizumab in Patients with Advanced Solid Tumors

18 years - 99 years
All genders
Phase 2
Interventional
The purpose of this study are to determine the maximum dose of FF-10832 that can be tolerated when taken in combination with pembrolizumab and to determine whether FF10832 taken by itself or in combination with pembrolizumab has anti-tumor activity.
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A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum

99 years or below
All genders
Interventional
The purpose of this study is to compare the effectiveness and implementation of two suicide prevention strategies for autistic youth: the Safety Planning Intervention tailored for Autistic individuals (SPI-A) and SPI-A plus follow-up care (SPI-A+). Participants are 150 clinicians and 1500 autistic youth (ages 15-24) who receive either SPI-A or …
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EASE: The Materna Prep Pivotal Study

99 years or below
Female
Interventional
This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery. Eligible participants will be women ages 18+ scheduled for vaginal birth.
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A Study of Venetoclax (ABT-199) in Combination with Liposomal Vincristine in Patients with Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia

A Study of Venetoclax (ABT-199) in Combination with Liposomal Vincristine in Patients with Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia

18 years - 99 years
All genders
Phase 1
Interventional
This study is being done to determine what effects the therapy venetoclax has on acute lymphoblastic leukemia (ALL).This investigational therapy will be added to what is a standard, liposomal vincristine, to treat relapsed ALL.
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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation after CABG

19 years - 99 years
All genders
Interventional
The purpose of the research is to compare two commonly used treatment strategies for managing atrial fibrillation after cardiac surgery. Patients 18 yrs. or older are randomized within 7 days after scheduled to undergo coronary artery bypass grafting (CABG), also known as bypass surgery. Only patients that undergo isolated CABG …
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A Study of DCC-3116 as Monotherapy and Combination Therapy in Patients With MAPK Pathway Mutant Solid Tumors

A Study of DCC-3116 as Monotherapy and Combination Therapy in Patients With MAPK Pathway Mutant Solid Tumors

18 years - 99 years
All genders
Phase 1
Interventional
This is a Phase 1/2, multicenter, open label, study of DCC-3116 as monotherapy, and in combination with trametinib, binimetinib, or sotorasib in patients with advanced or metastatic solid tumors with RAS/MAPK pathway mutation. The study consists of 2 parts, a dose-escalation phase, and an expansion phase.
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Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation (BRCA-P)

Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation (BRCA-P)

25 years - 55 years
Female
Phase 3
Interventional
This phase III trial compares denosumab to placebo for the prevention of breast cancer in women with a BRCA1 germline mutation. Research has shown that denosumab may also reduce the risk of developing breast cancer in women carrying a BRCA1 germline mutation.
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Antithrombotic Strategies in Hospitalized Adults with COVID-19

18 years - 99 years
All genders
Interventional
The purpose of this study is to compare the effectiveness of antithrombotic strategies for prevention of adverse outcomes in COVID-19 positive inpatients. Doctors use anticoagulation medicines, known as “blood thinners”, to lower the risk of blood clots forming in blood vessels (veins and arteries). The chance of blood clots in …
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Study to evaluate 6-week treatment cycles of rozanolixizumab in study participants with gMG.

18 years - 99 years
All genders
Phase 3
Interventional
The research study is being conducted to test the long-term safety, tolerability and effectiveness of rozanolixizumab in adult patients with generalized myasthenia gravis (MG) who have already taken part in the MG0003 study and is intended to replace MG0004. This study will evaluate 6-week treatment cycles of rozanolixizumab in study …
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Trial of anti-B Cell Maturation Antigen Chimeric Antigen Receptor T Cell Therapy for Multiple Myeloma Patients with Sub-Optimal Response After Autologous Hematopoietic Cell Transplantation and Maintenance Lenalidomide

99 years or below
All genders
We are doing this study to see if CAR T-cell therapy (bb2121) and maintenance therapy with the drug lenalidomide can help delay multiple myeloma from coming back.
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