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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence

18 years - 99 years
All genders
Phase 3
This is a study in participants with HER2-positive primary breast cancer who have received preoperative chemotherapy and HER2-directed therapy, including trastuzumab followed by surgery, with a finding of residual invasive disease in the breast and/or axillary lymph nodes
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A Study to Evaluate the Effectiveness and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis

A Study to Evaluate the Effectiveness and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis

18 years - 99 years
All genders
Phase 3
Interventional
AL (or light chain) amyloidosis begins in the bone marrow where abnormal proteins misfold and create free light chains that cannot be broken down. These free light chains bind together to form amyloid fibrils that build up in the extracellular space of organs, affecting the kidneys, heart, liver, spleen, nervous …
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Study of ASTX295 in Patients With Solid Tumors With Wild-Type p53

Study of ASTX295 in Patients With Solid Tumors With Wild-Type p53

18 years - 99 years
All genders
Phase 1
Interventional
ASTX295 is a synthetic small molecule that acts as an antagonist of Murine Double Minute 2 (MDM2; human homolog also known as HDM2). Study ASTX295-01 is a study with ASTX295 in subjects who are refractory or have relapsed after treatment with standard of care therapies, or for whom standard life-prolonging …
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Maintenance Niraparib and Dostarlimab in Advanced Cholangiocarcinoma

Maintenance Niraparib and Dostarlimab in Advanced Cholangiocarcinoma

18 years - 99 years
All genders
Phase 2
Interventional
A trial, evaluating molecularly selected, immune-based combination therapy in maintenance treatments for advanced cholangiocarcinoma, selecting patients on the homologous recombination deficient (HRD) signature.
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Observation of Residual Cancer With Liquid Biopsy Evaluation (ORACLE)

Observation of Residual Cancer With Liquid Biopsy Evaluation (ORACLE)

18 years - 99 years
All genders
Observational
The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA test results are linked to clinical outcomes in order to demonstrate clinical validity for recurrence detection and …
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AcQblate Force Sensing Ablation System US IDE for Atrial Flutter

AcQblate Force Sensing Ablation System US IDE for Atrial Flutter

18 years - 99 years
All genders
Interventional
The objective of the clinical study is to demonstrate the AcQBlate Force Sensing System is safe and effective when used to ablate the cavotricuspid isthmus (CTI) for the treatment of typical atrial flutter .
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Featured study
A study of near infrared imaging of myocardial scar and epicardial ganglionated plexus in patients undergoing cardiac surgery

A study of near infrared imaging of myocardial scar and epicardial ganglionated plexus in patients undergoing cardiac surgery

18 years - 99 years
All genders
Observational
To determine the feasibility of near infrared (NIR) imaging of myocardial scar and epicardial adipose tissue in patients undergoing cardiac surgery.
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A Safety, Pharmacokinetic, Pharmacodynamic and Anti-Tumor Study of PF-06873600 as a Single Agent and in Combination With Endocrine Therapy

A Safety, Pharmacokinetic, Pharmacodynamic and Anti-Tumor Study of PF-06873600 as a Single Agent and in Combination With Endocrine Therapy

18 years - 99 years
Male
Phase 1
Interventional
Open-label, multi-center, non-randomized, multiple dose, safety, tolerability, pharmacokinetic, and pharmacodynamics and clinical activity study of PF-06873600 administered as a single agent and then in combination with endocrine therapy. The study contains two parts, a Part 1 single agent dose escalation and combination endocrine therapy dose finding component and a Part …
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Measurement of B cell maturation antigen-Directed CAR T Cells During TAK-573 Study Participation

Measurement of B cell maturation antigen-Directed CAR T Cells During TAK-573 Study Participation

1 years - 99 years
Male
Interventional
The primary objective of this pilot study is to explore in a preliminary fashion whether administration of TAK-573 increases the number of BCMA-specific T cells in blood samples from patients with myeloma.
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Multimodal Evaluation of Spaceflight Participants Health Space Adventures 1 (MESH SPA-1)

Multimodal Evaluation of Spaceflight Participants Health Space Adventures 1 (MESH SPA-1)

18 years - 99 years
All genders
Observational
One commercial astronaut spending 2 weeks on the international space station will be participate in pre- and post-flight research by several investigators. The team at the University of Pennsylvania investigates cognitive performance, alertness and mood as well as changes in activity, heart rate and blood oxygen concentration as measured with …
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