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Found 1216 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

18 years - 99 years
All genders
Interventional
The purpose of this research study is to compare the performance of the investigational (experimental) tricuspid valve repair system plus optimal drug therapy with optimal drug therapy alone. Participants will be randomly assigned to treatment with either the TriClip device (device group) or No TriClip device (control group). Participants will …
18 years - 75 years
All genders
Phase 2
Interventional
The purpose of this study is to determine the safety and tolerability of an experimental medication PLN-74809 to treat primary Sclerosing Cholangitis (PSC), a rare, long-term liver disease affecting the bile ducts (small tubes) inside and outside the liver. Participants will visit the study center 8 times within 22 weeks. …
70 years - 99 years
All genders
Phase 2
Interventional
This study will test danicopan, a new drug that is being developed by Alexion to slow down progression of GA. The goals of this study are as follows: • To find out whether danicopan can slow the rate of GA disease progression, and in turn slow the loss of visual …
18 years - 99 years
All genders
Phase 3
Interventional
The purpose of this study is to test a new drug called AGN-151586 as a treatments for patients with moderate to severe frown lines between the eyebrows (glabellar) over a period of 18 weeks. Procedures include Vital signs, Physical Exam, Medical History, Blood and Urine tests, ECG, Neurological exam and …
 Study of Immune Checkpoint Inhibition with Chemotherapy in Treatment-Na ve Metastatic Anal Cancer Patients
18 years - 99 years
All genders
Interventional
This trial compares the addition of nivolumab to chemotherapy (carboplatin and paclitaxel) versus usual treatment (chemotherapy alone) for the treatment of anal cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor …
40 years - 99 years
All genders
Interventional
The purpose of this study is to test letermovir when given to people who have both well-controlled HIV infection and asymptomatic CMV infection. This study will also gather data on the effectiveness of letermovir to reduce inflammation when compared to no anti-CMV study treatment. In addition, the study will collect …
 A Phase 1/2a Study to Evaluate the Safety, Tolerability, Immunogenicity, andAnti-Tumor Activity of GEN-009 Adjuvanted Vaccine in Adult Patients with Selected SolidTumors
18 years - 99 years
All genders
To evaluate an investigational, personalized adjuvanted vaccine, GEN-009, that is being developed for the treatment of patients with solid tumors. A personalized vaccine, consisting of between 4 to 20 synthetic long peptides, will be generated for each patient and shall be administered as an adjuvanted vaccine, with the adjuvant Hiltonol.
18 years - 99 years
All genders
Interventional
This is an extension study for subjects over the age of 18, diagnosed with moderate-to-severe atopic dermatitis and enrolled in our main study IRB # 845325. This research study is being conducted to test the safety of lebrikizumab and potential side effects. Procedures include Physical exams, Medical History, blood and …
 An Open-Label Study For Continued Treatment Access For Participants From The B9991032 Avelumab Study
18 years - 99 years
All genders
Phase 2
The purpose of the continuation sub-study is to provide continued treatment access for participants from the B9991032 Parent Study who are deriving benefit from study treatment as judged by the investigator.
18 years - 99 years
All genders
The purpose of this study is to assess the safety of ALM-488, and to learn how well it shows nerve tissue in the body.
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