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Found 1243 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Phase III Randomized Double-Blind Placebo-Controlled Study of Atezolizumab With or Without Tiragolumab (Anti-Tigit Antibody) in Patients with Unresectable Locally Advanced Esophageal Sqamous Cell Carcinoma

A Phase III Randomized Double-Blind Placebo-Controlled Study of Atezolizumab With or Without Tiragolumab (Anti-Tigit Antibody) in Patients with Unresectable Locally Advanced Esophageal Sqamous Cell Carcinoma

99 years or below
All genders
The purpose of this study is to compare the effects of atezolizumab plus tiragolumab versus atezolizumab plus placebo or double placebo on subjects with esophageal cancer who have had at least 2 cycles of chemoradiotherapy without progression of their disease. Subjects with unresectable, locally advanced esophageal cancer will receive either …
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Long-Term Follow-Up Study of Patients Who Have Received Gene-Modified Cell Therapy Produced by Ex Vivo Transduction of Immune Cells Expressing Viral or Non-Viral Vector in Trials

Long-Term Follow-Up Study of Patients Who Have Received Gene-Modified Cell Therapy Produced by Ex Vivo Transduction of Immune Cells Expressing Viral or Non-Viral Vector in Trials

99 years or below
All genders
This is an observational follow-up study of patients who have been exposed to a CAR-T cell treatment that was produced by ex vivo transduction with a CAR-expressing retroviral vector in studies sponsored by Sorrento Therapeutics, Inc. Patients are to be followed for up to 15 years after exposure to a …
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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1 BRCA2 or PALB2 Mutation

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1 BRCA2 or PALB2 Mutation

18 years - 99 years
All genders
The purpose of this study is to compare the usual treatment alone to using one year of olaparib. We will enroll subject who have been diagnosed with pancreatic cancer and have undergone surgery to remove the cancer. Only patients who are found to have a BRCA1, BRCA2 or PALB2 mutation …
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Liver Transplantation from Normothermic Regionally Perfused Deceased Cardiac Death Organ Donors

Liver Transplantation from Normothermic Regionally Perfused Deceased Cardiac Death Organ Donors

18 years - 99 years
All genders
The purpose of this study is to evaluate the outcomes of liver transplant when the donor is placed on a normothermic perfusion machine prior to donation of the liver. The perfusion machine restores oxygenated blood flow to organs in the abdomen such as the liver. The use of the machine …
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TRILOGY

TRILOGY

18 years - 65 years
All genders
The target population are patients at Penn Medicine undergoing elective bariatric surgery; and are additionally participating in POW-R study ( Protocol #843280) Patients will be recruited to undergo liver wedge and visceral adipose tissue biopsy and provide blood samples. Liver samples will be processed for RNA, metabolomics, and biochemical and …
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Cooling to Help Injured lungs (CHILL) for Therapeutic Hypothermia in Patients with ARDS (acute respiratory distress syndrome )

Cooling to Help Injured lungs (CHILL) for Therapeutic Hypothermia in Patients with ARDS (acute respiratory distress syndrome )

18 years - 65 years
All genders
Phase 2
This study will analyze the potential lung protective effect of mild therapeutic hypothermia (TH), similar to that used for cardiac arrest, in ICU patients with acute respiratory distress syndrome (ARDS).
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UPCC 12119: An Exploratory Biomarker Study of Metastatic Triple-Negative Breast Cancer Patients Treated with Immune Checkpoint Inhibitors

UPCC 12119: An Exploratory Biomarker Study of Metastatic Triple-Negative Breast Cancer Patients Treated with Immune Checkpoint Inhibitors

18 years - 99 years
All genders
Interventional
The purpose of this research is to collect clinical information and research tissue samples (blood, tissue, and stool) from patients receiving standard treatment for metastatic triple-negative breast cancer to help researchers better understand the use of immunotherapy in breast cancer.
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Study: A Randomized Double Blind Phase II Study of Dabrafenib and Trametinib With or Without Hydroxychloroquine in Advanced BRAF V600E/K Melanoma With Elevated LDH

Study: A Randomized Double Blind Phase II Study of Dabrafenib and Trametinib With or Without Hydroxychloroquine in Advanced BRAF V600E/K Melanoma With Elevated LDH

18 years - 80 years
All genders
This phase II trial investigates how well adding hydroxychloroquine to the standard treatment of dabrafenib and trametinib works to overcome resistance and delay disease progression in treating patients with stage IIIC or IV BRAF V600E/K melanoma. Giving hydroxychloroquine together with dabrafenib and trametinib may work better than dabrafenib and trametinib …
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Clinical Trial Readiness for SCA1 and SCA3

Clinical Trial Readiness for SCA1 and SCA3

18 years - 65 years
All genders
Interventional
The prospective study is to establish the world's largest cohort of premanifest and early-stage SCA1 and SCA3 individuals.
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I-SPY COVID TRIAL: An Adaptive Platform Trial to Reduce Mortality and Ventilator Requirements for Critically Ill Patients

I-SPY COVID TRIAL: An Adaptive Platform Trial to Reduce Mortality and Ventilator Requirements for Critically Ill Patients

18 years - 99 years
All genders
Interventional
A trial to compare different investigational agents for their ability to improve clinical outcomes n severely ill patients with COVID-19 pneumonia.
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