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Found 1253 All Conditions trials

A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase (DISRUPT)

Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase (DISRUPT)

12 years - 99 years
All genders
Phase 3
Interventional
The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S. aureus) bloodstream infections (BSI), including right-sided infective endocarditis (IE). Patients will be randomized to …
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Online study
Cancer Therapy Risk-Reduction with Intensive Systolic BP Management (CARISMA)

Cancer Therapy Risk-Reduction with Intensive Systolic BP Management (CARISMA)

18 years - 99 years
All genders
Phase 2
Interventional
This phase II trial studies how well intensive blood pressure management works in decreasing systolic blood pressure in patients with kidney or thyroid cancer that has spread to other places in the body (metastatic) who are starting anti-angiogenic tyrosine kinase inhibitor cancer therapy. This study is being done to find …
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Online study
Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide (ACCESS)

Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide (ACCESS) (ACCESS)

All genders
Phase 2
Interventional
This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. Post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate mofetil (MMF) will be used for for …
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Online study
The Effects of IQOS Use on Cigarette Smoking Behaviors

The Effects of IQOS Use on Cigarette Smoking Behaviors

18 years - 65 years
All genders
Interventional
The purpose of this study is to examine the effects of IQOS use on cigarette smoking behavior. IQOS is a commercially available Heat-Not-Burn nicotine delivery product, which is an electronic device that heats tobacco at a constant temperature rather than burning it. The IQOS device contains a small, disposable tobacco …
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Early Diagnosis of TTR Amyloid

Early Diagnosis of TTR Amyloid

40 years - 75 years
All genders
Interventional
The purpose of this study is to find out if we can detect a disease of the heart called cardiac transthyretin (TTR) amyloidosis early. People develop cardiac TTR amyloidosis due to an accumulation of a transthyretin protein in the heart. This can happen as part of an aging process (wild …
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The POLAR Trial - Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of PretermInfants at Birth

The POLAR Trial - Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of PretermInfants at Birth

All genders
Phase 3
Interventional
The POLAR Trial - Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants  at Birth
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A Randomized Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

A Randomized Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

18 years - 82 years
All genders
Phase 3
Interventional
A Phase 3 Global, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Hereditary Transthyretin-Mediated Amyloid Polyneuropathy. For those with : a. Stage 1 or Stage 2 according to the Familial Amyloid Polyneuropathy (FAP) or Coutinho Stage b. Documented genetic mutation in the TTR gene …
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A Open-Label Ascending Dose Study to Evaluate the Safety and Effects of PR001A in Patients With Parkinson's Disease

A Open-Label Ascending Dose Study to Evaluate the Safety and Effects of PR001A in Patients With Parkinson's Disease

35 years - 80 years
All genders
Phase 1
Interventional
This is a 5 year study and the purpose is to assess the safety and tolerability of 2 dose levels of PR001A administered via l injection in patients with moderate to severe Parkinson's Disease
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Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

18 years - 99 years
Female
Phase 3
Interventional
This phase III trial compares whether the addition of pembrolizumab to radiation therapy is more effective than radiation therapy alone in reducing the risk of cancer coming back (recurrence) in patients with newly diagnosed stage I-II endometrial cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune …
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First-Line Treatment of Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

First-Line Treatment of Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

18 years - 99 years
All genders
Phase 3
Interventional
This is a Phase 2 study of enoblituzumab combined with either retifanlimab or tebotelimab administered as first-line treatment to patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
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