API Push Trial without Cancer condition at attribute

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Age

99 years or below

Gender

All

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Brief description of study

To evaluate the efficacy of ONC201 administered following radiotherapy in participants with H3 K27Mmutant diffuse glioma. To assess plasma concentrations and estimate PK parameters for ONC201. To evaluate the efficacy of ONC201 using RANO-LGG criteria. To evaluate the impact of ONC201 treatment on health care resource
utilization.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Medical Research
Age: 99 years or below
Gender: All

TBD

The purpose of this research study is to learn about the effects of a study medicine given after radiotherapy in people with H3 K27M-mutant diffuse glioma (a type of brain tumor). The study will also look at how much of the study medicine is in the blood and estimate how the body processes it.

Participants will receive the study medicine after they have radiotherapy. The study team will measure levels of the study medicine in blood (plasma) and will evaluate the tumor using a standard set of criteria for low-grade glioma (RANO-LGG). The study will also track health care resource use during treatment.

Updated on 30 Apr 2026. Study ID: 20260407-4

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Study of a Study Medicine After Radiotherapy for H3 K27M-Mutant Diffuse Glioma

Brief description of study

Eligibility of study

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