This study is a registry for patients who have sickle cell disease (SCD), including pregnant women. A registry is a database of patient health and demographic information that is used to understand how a disease affects different people based on, for example, their other medical conditions, their age, or their treatment regimen. The purpose of this project is to examine specific and additional biomarkers in both steady state and in crisis to see if associations can be identified between these biomarkers and sickle cell disease. The successful characterization of biomarkers in sickle cell disease may prove to be helpful in risk-stratifying patients and could be a powerful tool in clinical trials of new therapies. Participants will do the following: - Have Data collection from health records on a yearly basis as part of a routine follow-up visit. This data will be stored in a registry. - Complete regular surveys about their sickle cell disease during office visits or online - Optional collection of bio samples

You may be eligible for this study if you meet the following criteria:

• Conditions: Sickle Cell Disease
• Age: 99 years or below
• Gender: All