Pilot Study of a Multi-System Analysis of Opioid Receptor Binding

Study of Mu Opioid Receptor Binding Using PET/CT Imaging

Age
18 years - 50 years
Gender
All
participants needed
60
Location
1
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Pilot Study of a Multi-System Analysis of Opioid Receptor Binding

Brief description of study

The purpose of this research is to learn more about mu opioid receptor (MOR) binding in the brain and body.

This study will enroll up to 60 adults in three cohorts of up to 20 participants each:
  • Cohort 1: Subjects with a lifetime diagnosis of Opioid Use Disorder (OUD) on a stable dosage of buprenorphine or methadone for medication-assisted treatment (MAT) for at least four weeks prior to the screening visit
  • Cohort 2: Subjects with a lifetime history of OUD, but not current OUD who have not received MAT for OUD during the 12 months prior to screening
  • Cohort 3:  Subjects without a lifetime history of OUD
In this study, we examine the distribution of a kind of receptor that binds opioids (opioids are chemicals that are either produced normally by the body or taken as medications, like morphine or codeine, which are prescribed by doctors to reduce pain). These opioid receptors, which are widely distributed in the brain and other organs, such as the intestines, are involved in the experience of reward, and they play a role in reducing pain. We will study this using a type of Positron Emission Tomography (PET/CT) scan using a radioactive imaging drug called [11C]carfentanil that binds to this type of receptor.
 
[11C]carfentanil is an experimental  radioactive imaging drug used in PET imaging  to measure mu-opioid receptors (MORs) in various organs in the body, including the brain. [11C]carfentanil has not yet been approved by the Food and Drug Administration (FDA) for use except in a research study. The use of [[11C]carfentanil in this study is allowed under an Investigational New Drug Application approved by the FDA. 

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Healthy Controls,Opioid Use Disorder,History of Opioid Use Disorder,Opiate use,Opioid Use
  • Age: 18 years - 50 years
  • Gender: All


The purpose of this research study is to learn more about mu opioid receptor binding in the brain and body. Mu opioid receptors are a type of receptor that binds opioids, which are chemicals made by the body and also found in some pain medicines.

Participants will be in 1 of 3 groups: (1) adults with a lifetime diagnosis of opioid use disorder who are on a stable dose of buprenorphine or methadone for treatment, (2) adults with a lifetime history of opioid use disorder but not current opioid use disorder and who have not received medication treatment for opioid use disorder in the past year, or (3) adults without a lifetime history of opioid use disorder. Participants will have a PET/CT scan (a type of imaging scan) using a radioactive imaging drug that binds to mu opioid receptors. This radioactive imaging drug is only allowed for use in research studies and is not approved for general use.

Who can participate:
Adults may be able to participate if they:

  • Have a lifetime diagnosis of opioid use disorder and have been on a stable dose of buprenorphine or methadone for at least 4 weeks
  • Or have a lifetime history of opioid use disorder but do not currently have opioid use disorder and have not received medication treatment for opioid use disorder in the past 12 months
  • Or do not have a lifetime history of opioid use disorder

Updated on 04 Aug 2024. Study ID: 851051

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