Open Fracture Population Eligibility Criteria: 1. Patients 18 years of age or older. 2. Open fracture of the appendicular skeleton. 3. Received or will receive definitive fracture treatment with a surgical implant(s) (i.e. internal fixation, external fixation, joint prosthesis, etc.). 4. Open fracture wound management that includes formal surgical debridement within 72 hours of their injury. 5. Will have all planned fracture care surgeries performed by a participating surgeon or delegate. 6. Informed consent obtained. 7. Patient enrolled within 3 weeks of their fracture. Closed Fracture Population Eligibility Criteria: 1. Patients 18 years of age or older. 2. Closed fracture of the lower extremity or pelvis. 3. Received or will receive definitive fracture treatment with a surgical implant(s) (i.e. internal fixation, external fixation, joint prosthesis, etc.). 4. Fracture management requires a surgical incision (i.e. for fracture reduction or implant insertion). 5. Will have all planned fracture care surgeries performed by a participating surgeon or delegate. 6. Informed consent obtained. 7. Patient enrolled within 3 weeks of their fracture.