Prescribed opioid induced brain damage in chronic pain

Build status - In Progress

Recruiting

18 years - 50 years

All

Phase N/A

30 participants needed

1 Location

Brief description of study

Opioids activate the limbic system and results in acute cell injury hippocampal atrophy. The

specific aims of this proposal are to test the hypotheses that humans with chronic pain on longterm,

high-dose opioids: 1. Will demonstrate smaller hippocampal volumes by MRI. 2. Will

perform more poorly on neuropsychological tests of memory and associated hippocampal

functions. Targeted Population: pts taking chronic opioids for back pain Procedures: MRI and

neuropsychological cognitive tests

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Pain,Opioid
Age: 18 years - 50 years
Gender: All

Inclusion Criteria:

(1) Chronic lower back pain greater than two years,

(2) PA, NJ , DE residents in the UPenn system for at least 2 years (for PDMP evaluation)

(3) for the opioid group, use of only full mu opioid agonists (morphine, fentanyl, oxycodone) for at least two years with at least 90 MED per day

Exclusion Criteria:

(1) Pregnancy,

(2) MRI contraindications,

(3) Unable to speak/read English,

(4) Comorbid CNS disease that would interfere with informed consent and evaluation of results,

(5) evidence of chronic intake of other confounding drugs (cannabis, benzodiazepines, gabapentin, selective serotonin reuptake inhibitors/antidepressants, pregabalin, illicit drugs) on urine drug tests, PDMP, patient history, EMR.

Updated on 04 Aug 2024. Study ID: 849105

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Prescribed opioid induced brain damage in chronic pain patients

Brief description of study

Eligibility of study

Find a site

Interested in the study