Towards Objective Metrics to Quantify the Role of HIV and Increasing Cognitive Demand on Instrumental ADLs in People Aging with HIV
Recruiting
50 years - 100 years
All
Phase
N/A
120 participants needed
1 Location
Brief description of study
The objective of this
proposal is to examine the utility of a robot-based approach to study instrumental activities of daily living (IADLs) function and cognitive-motor performance in persons aging with HIV. IADLs often require high levels of
executive functioning during the performance of motor activities, but there are
no good quantitative assessment strategies to capture impairments in IADL
function. HIV produces such impairments via accelerated aging and HIV-Associated Neurocognitive Disorders.
We
intend on applying these technological advancements to improve health outcomes
in individuals dealing with the complex interactions across HIV, aging, and
disability. We have developed a series of novel robot-based tasks whose metrics
show potential to objectively quantify gross and fine motor impairment in the
upper limb as well as cognitive impairment in the executive function domain in
older adults living with HIV. Our goal is to determine how these metrics relate
to and predict IADL function in older adults with and without HIV and what role
HIV plays in the management of motor tasks with increasing cognitive demands.
Detailed description of study
The study activities will take place at Rehabilitation Robotics Lab located at Penn Medicine Rittenhouse at 1800 Lombard Street, Philadelphia, PA 19146.
We are looking for two types of individuals:
1) Participants for our control group: Healthy people without HIV and without brain impairments who are above the age of 50.
2) Participants for our Test group: People with HIV who are above the age of 50.
The study should only take one session of approximately three hours with rest times built in and involves you completing cognitive and motor clinical assessment scales and then using a robot to complete several tasks.
The study pays $50.00 compensation at the end of the session.
Our aims are the following:
Aim 1: To assess a novel
robot-based motor and cognitive task with existing clinical tools used to
predict motor impairment, cognitive impairment and IADL function in older
adults living with HIV. In a
cross-sectional study, 21 participants aging with HIV and 21 non-HIV controls with
varying levels of motor function will be evaluated using our robot-based gaming and gold standard
clinical tests relating to instrumental activities daily living (IADL) function, gross and
fine motor function, and executive function.
Aim 2:
To assess interactions between increasing cognitive demand and motor
performance in older adults living with HIV and controls without HIV. In a
cross-sectional study, 36 participants with HIV and 23 matched controls will be
evaluated using our novel robot-based gaming task. In this aim,
we will vary the cognitive difficulty of the robot-based task and measure
changes in motor performance as a function of three levels of task difficulty.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Healthy,HIV,AIDS
-
Age: 50 years - 100 years
-
Gender: All
Key eligibility requirements:
Older Adults with HIV/AIDS (50 years or older)
on Anti-retroviral treatment
Able to complete tasks
Controls:
Healthy Older Adults (50 years and older)
Updated on
04 Aug 2024.
Study ID: 844802
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