Changes in the Lymphatic System on the MR | Clinical Research Studies Listing

Recruiting

18 years - 100 years

All

Phase 1

30 participants needed

1 Location

Brief description of study

This is an observational study that will compare the differences in lymphatic flow and anatomy of the central lymphatic system on MRL in the liver cirrhosis patients with and without ascites. In the second part of the study, MRL anatomical and flow changes in the central lymphatic system of patients with liver cirrhosis will be compared to normative data in healthy individuals.

In ascites group, the degree of anatomical and lymphatic flow changes on MRL will be then correlated with volume of the ascites.

Detailed description of study

Our group routinely uses MR Lymphangiography (MRL) in a clinical setting to image the lymphatic system in patients with plastic bronchitis, chylothorax and lymphangiomatosis (13). This new technique allowed imaging and physiological evaluation of the central lymphatic system that includes cisterna chyli and the thoracic duct. MRL not only allowed for understanding of the pathophysiology of these disorders, but also provided an excellent tool in planning of the interventional procedure.

The goal of this study is to compare the changes in the central lymphatic system in liver cirrhosis patients with and without the ascites.

We believe that the application of MRL in patient with liver cirrhosis will be an effective means to assess flow velocity and volume in the thoracic duct. It can further provide valuable insight into the pathophysiology of changes in the lymphatic flow in the central lymphatic system in patient with liver cirrhosis and ascites. We hope that our study will shed light on pathophysiology of the ascites in liver cirrhosis.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Healthy
Age: 18 years - 100 years
Gender: All

· Participants must be age 18 or older

· Participants have to be able to lie flat for at least one hour

· Participants must be able to understand English and be able to review and comprehend the informed consent form independently or with the help of research staff

· Participants must sign the informed consent form

Normal participants:

· Absence of any signs or symptoms consistent with liver cirrhosis

· Absence of any regularly-prescribed medication

· Participants must be age 18 or older

· Participants have to be able to lie flat for at least one hour

Updated on 04 Aug 2024. Study ID: 829482

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Changes in the Lymphatic System on the MR Lymphangiography (MRL) In Patients with Liver Cirrhosis

Brief description of study

Detailed description of study

Eligibility of study

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