This is a pragmatic randomized clinical trial in which patients with locally advanced breast cancer will be randomized to either proton or photon therapy and followed longitudinally for cardiovascular morbidity and mortality, health-related quality of life (HRQOL), and cancer control outcomes. We hypothesize that proton therapy, as part of multi-modality curative treatment for locally-advanced breast cancer, reduces major cardiovascular events (MCE), is non-inferior in cancer control, and improves HRQOL compared to photon therapy, the current standard treatment.

You may be eligible for this study if you meet the following criteria:

• Conditions: breast cancer
• Age: 99 years or below
• Gender: All