Found 36 Viral Infections trials
A listing of Viral Infections medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A Multiple-Site Phase 1/2 Safety and Efficacy Trial of a Recombinant Adeno-associated Virus Vector Expressing CNGB3 (rAAV2tYF-PR1.7-hCNGB3) in Patients with Congenital Achromatopsia Caused by Mutations in the CNGB3 Gene
Achromatopsia is an inherited retinal disorder characterized by markedly reduced visual acuity, nystagmus, photoaversion (intolerance to bright light), a small central scotoma, eccentric viewing, and complete or severe loss of color discrimination. The genetic mutations of the disease can be established in the majority of individuals. Approximately 50% are caused …
Use of Tecovirimat (TPOXX ) for Treatment of Human Orthopoxvirus Infections
The purpose of this study is to test the use of Tecovirimat (TPOXX ) for Treatment of Human Orthopoxvirus Infections. Tecovirimat (also known as TPOXX or ST-246) is a drug that may help to treat infections caused by pox viruses and reactions to the smallpox vaccine. Eligible Participants: • Have …
Trial to Evaluate a Modified Vaccine (Triplex ) in Adults with HIV-1 and CMV Who Are on Potent Combination ART with Conserved Immune Function
The purpose of this study is to see if an investigational vaccine for cytomegalovirus (CMV), called Triplex®, is safe when given to people with both Human Immunodeficiency Virus (HIV) and CMV.
A Phase 1 Study of IL-15 Superagonist (N-803) and Broadly Neutralizing Antibodies to Induce HIV-1 Control
This study will investigate whether N-803, a new experimental drug that stimulates the immune system, is safe and tolerable when given alone and in combination with two new experimental drugs that are antibodies (natural proteins that the body makes in response to an infection) to HIV (the virus that causes …
Study of SAR441236, a Tri-specific Broadly Neutralizing Antibody, in Participants with HIV
The purpose of this study is to test the safety of SAR441236, a study drug that has not been tested in humans before now. The study will also look at how long SAR441236 stays in the body after one dose and after four doses. It will also look at whether …
AMC 083 / UPCC 12716: Tissue Acquisition for Analysis of Prognostic Factors Immunology and Genetic Progression of HIV-1 Associated Malignancies
The main purpose of this study is to collect tissue from people diagnosed with HIV-associated cancer. We will use these samples to look for genetic changes associated with HIV- and other virus-related cancers. This may lead to better ways of preventing, detecting, and treating HIV-associated cancers.
HOPE in Action Prospective Multicenter Clinical Trial of HIV+ Deceased Donor Kidney Transplants for HIV+ Recipients
Use of an HIV+ deceased donor could increase the risk of death, transplant-related or HIV-related complications; alternatively with effective antiretroviral treatment and careful HIV+ donor selection, these risks may be comparable to kidney transplant using an HIV-negative donor. We hypothesize that receiving a kidney transplant from an HIV+ donor will …
A Phase III Randomized Placebo-Controlled Study to Examine the Efficacy and Safety of DAS181 for the Treatment of Lower Respiratory Tract Parainfluenza Infection in Immunocompromised Subjects
This purpose of this study is to see if an investigational inhaled medication is safe and effective for the treatment of parainfluenza virus(PIV) in patients with weakened immune systems. Key eligibility criteria are being diagnosed with PIV having received a solid organ or stem cell transplant at any time in …
Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV
The research study is being conducted to examine the effects of personalized smoking cessation medication treatment in order to help people with HIV/AIDS to quit smoking. During the study, participants will take either varenicline (brand name Chantix®) or use the nicotine patch, and they will receive smoking cessation therapy with …
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