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Found 22 Mitral Valve Regurgitation trials

A listing of Mitral Valve Regurgitation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 Pilot study for functional and structural MR Imaging of Endobroncial valve recipients using hyperpoloarized XENON-129

Pilot study for functional and structural MR Imaging of Endobroncial valve recipients using hyperpoloarized XENON-129

All genders
We propose to use gas Magnetic Resonance Imaging (MRI) using the inhaled contrast agent, hyperpolarized (HP) xenon-129, to study the lungs of 20 volunteers who have received or will receive endobronchial valve (EBV) therapy as a treatment for COPD. Since its recent FDA approval, investigators have yet to explicitly assess …

FOLLOW-UP VESSEL WALL MR IMAGING TO EXPLORE SEX-DIFFERENCES OF INTRACRANIAL ARTERIAL WALL CHANGES AND INTRACRANIAL ATHEROSCLEROTIC PLAQUE TREATMENT EFFICACY

All genders
Mortality related to cardiovascular disease in the US is improving. Yet the rate of decline is less for women than for men. Women's health is unique due to the varying reproductive stages, and differences are further heightened by sex-specific molecular and cellular characteristics of the heart and vasculature. These biophysiological …

Investigating Potential of Personalized Biomarkers in Redefining Treatment Response in Patients with Glioblastoma using Multiparametric MRI and Liquid Biopsy

All genders
This study aims to investigate 30 patients with a diagnosis of Glioblastoma to develop a decision support system by incorporating advanced MR imaging, liquid biopsy, and MGMT promoter status to determine with higher accuracy whether tumor changes are true progression or pseudo progression. Analysis of these results will hopefully have …
 A study of the ReCor Medical Paradise System in Clinical Hypertension

A study of the ReCor Medical Paradise System in Clinical Hypertension

18 years - 99 years
All genders
Observational
The objective of TRIO CAP is to continue to collect safety and effectiveness data on the Paradise System in hypertensive subjects inadequately controlled with three antihypertensive medications, similar to those randomized in the RADIANCE-HTN Study TRIO Cohort, until the Paradise Ultrasound Renal Denervation System becomes commercially available. Reduction in average …

A Phase 2 Trial Of All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition In Recurrent IDH-Mutant Glioma

All genders
Phase 2
The purpose of this research study will be to evaluate the safety and effectiveness of two investigational drugs, All-trans retinoic acid (ATRA) and Retifanlimab (anti-PD1 monoclonal antibody), in treating recurrent IDH-mutant gliomas. Objective radiographic response (CR + PR + MR) using Response Assessment in Neuro-Oncology (RANO) criteria by measurable disease …

Vessel Wall Magnetic Resonance Imaging to Explore Gender Differences of Intracranial Arterial Wall Changes After Suspected Stroke

18 years - 99 years
All genders
Mortality related to cardiovascular disease in the US is improving. Yet the rate of decline is less for women than for men. Womens health is unique due to the varying reproductive stages, and differences are even greater due to gender-specific characteristics of the heart and vasculature. While women have some unique risk factors, …

Evaluating TRUFILL® n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System as a treatment of chronic subdural hematoma (cSDH)

18 years - 99 years
All genders
The objective of this study is to evaluate the safety and effectiveness of TRUFILLP Pn-BCA for MMA embolization in patients presenting with a cSDH compared to patients treated with standard of care management. Residual or re-accumulation of the cSDH (more than 10 mm) at 6 months as assessed by an …

Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts

40 years - 75 years
Accepts healthy volunteer
Female
500 patients will be prospectively recruited to undergo a fast breast MRI examination. The women will be recruited for the study will meet the following criteria: 1. African American 2. negative DBT examination 11 months prior to recruitment 3. Heterogeneously and Extremely breast densities 4. clinically asymptomatic- no palpable masses, …

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Male
Phase 3
Interventional
This phase III trial tests two questions by two separate comparisons of therapies. The first question is whether enhanced therapy (apalutamide in combination with abiraterone + prednisone) added to standard of care (prostate radiation therapy and short term androgen deprivation) is more effective compared to standard of care alone in …
 Physiologic MR Imaging in Distinguishing Benign from Malignant Salivary Gland Tumors

Physiologic MR Imaging in Distinguishing Benign from Malignant Salivary Gland Tumors

18 years - 99 years
All genders
The purpose of this research study is to help identify the difference between cancerous and non-cancerous salivary gland tumors for improving treatment strategies and also aid in the prediction of disease progression. It is important to determine whether the salivary gland tumor is cancerous prior to operation because this information …
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