Found 18 Glioblastoma multiforme trials
A listing of Glioblastoma multiforme medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A Phase II Study of the Anti-GITR Agonist INCAGN01876 and the PD-1 Inhibitor INCMGA00012 in Combination with Stereotactic Radiosurgery in Recurrent Glioblastoma
The following protocol is a phase II study of the combination of the GITR agonist monoclonal antibody INCAGN01876, the anti-PD1 monoclonal antibody INCMGA00012, and SRS for recurrent GBM. We hypothesize that the proposed regimen will be safe and stimulate a robust anti-tumor immune response and result in improved tumor responses. …
A Phase 2/3 Randomized Open-Label Study of Toca 511 a Retroviral Replicating Vector Combined With Toca FC versus Standard of Care in Subjects Undergoing Planned Resection for Recurrent Glioblastoma or Anaplastic Astrocytoma
This is a multicenter, randomized, open-label study of Toca 511 and Toca FC versus standard of care (SOC) that comprises Investigators choice of either single agent chemotherapy (lomustine or temozolomide) or bevacizumab administered to subjects undergoing resection for first or second recurrence (including this recurrence) of glioblastoma or anaplastic astrocytoma. …
ImmuneSense Study- Safety and Efficacy of IGV-001 an Autologus Cell Immunotherapy With Antisense Oligonucleotide (IMV-001) Targeting IGF-1R in Newly Diagnosed Patients With Glioblastoma Multiforme
The purpose of this study is to see how safe the study medicine, IGV-001 plus standard of care (SOC), is and to compare IGV-001 with placebo (only standard of care) to see if it works in slowing GBM tumor regrowth. Participants for this study will be recruited from the patient …
Whole-Brain Spectroscopy Guided Personalized Delivery of Tumor Treating Fields in Glioblastoma Patients
The research study is for Glioblastoma (GBM) patients beginning Optune, a therapy that uses - tumor treating fields (TTFields). As a part of this study participants will either receive Optune with standard treatment array mapping from MR imaging or an alternative treatment array mapping based on advanced MR imaging also …
Phase II Trial of Pembrolizumab and Reirradiation in Bevacizumab Naive and Bevacizumab Resistant Recurrent Glioblastoma
This is a multicenter, open-label, phase II trial of pembrolizumab plus re-irradiation among recurrent glioblastoma patients enrolled to two parallel, non-comparative treatment arms including patients who are bevacizumab naïve (Arm A, n=30) and patients who are bevacizumab-resistant (Arm B, n=30). All subjects must have histologically confirmed World Health Organization (WHO) …
Evaluating CART-EGFR-IL13Ra2 Cells Following Lymphodepleting Chemotherapy in Patients With EGFR-Amplified Recurrent Glioblastoma
This research study is being conducted to evaluate an experimental drug called CART EGFR-IL13Ra2 cells in patients with glioblastoma that has returned or worsened on current treatment.
Circulating Biomarkers for Glioma
Subjects will be recruited from the Radiation Oncology and Neurosurgery practices at the Hospital of the University of Pennsylvania. The treating radiation oncologist will determine if the patient is a potential research candidate and has the capacity to consent. The goal of this study is to collect and analyze blood …
GGDEF-32 Trident
The primary objective is to determine if TTFields to the brain concomitantly with RT and TMZ in the treatment of GBM patients prolongs the overall survival of patients, compared to RT and TMZ followed by TTFields and maintenance TMZ. Secondary objectives assess progression-free survival, 1 and 2 year survival rates, …
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