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Found 3 Depression (Treatment-Resistant) trials

A listing of Depression (Treatment-Resistant) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 Clinical Study to Evaluate the Efficacy and Safety of MK-1942 Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression
18 years - 65 years
Male
Phase 2
Normal 0 false false false EN-US X-NONE AR-SA This research study invites participants that are taking an antidepressant that has not fully helped with their depression. MK-1942 is the investigational product under study in this research trial, the participant will be taking along with their current antidepressant to test its …
99 years or below
All genders
Phase 3
this study is to evaluate the efficacy of each individual dose of esketamine nasal spray, 56 mg and 84 mg, compared with placebo nasal spray in improving depressive symptoms in participants with TRD, as assessed by the change from baseline in the Montgomery-Asberg Depression Rating Scale (MADRS) total score from …
 RECOVER: Safety and Effectiveness of VNS Therapy  System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
18 years - 99 years
All genders
The research study is being conducted to determine if active VNS (Vagus Nerve Stimulation) Therapy helps depression subjects compared to a no-stimulation control group. Patients with an established diagnosis with Treatment-Resistant Depression (TRD) and have been referred for treatment with the VNS Therapy® System will potentially qualify to participate in …