Found 387 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Cardiovascular function in leukemia patients: an observational prospective study
In the last decade, both the incidence and the survival of acute leukemia has been increasing. Therefore, detection of associated illnesses is important. We have recently observed that patients with acute leukemia treated with anthracyclines develop a high rate of symptomatic heart failure. To avoid this life-threatening illness, early detection …
UPCC 06518: A Phase 2 Precision Oncology Study of Biomarker-Directed Pembrolizumab-Based Combination Therapy for Advanced Non-Small Cell Lung Cancer
To evaluate the clinical activity (as assessed by objective response rate [ORR]) pembrolizumab (MK-3475) in combination with MK-4280 or lenvatinib in study participants with advanced non-small cell lung cancer (NSCLC) without prior systemic treatment for their advanced disease.
A Phase 1/2 Open-Label First-in-Human Study to Evaluate the Safety and Anti-Tumor Activity of FS118 a LAG-3/PD-L1 Bispecific Antibody in Patients with Advanced Malignancies
This research study is for those with you have advanced cancer. This research study is designed to learn more about the safety and effectiveness of FS118, an investigations drug given to individuals who have been diagnosed with advanced cancer.
Patients Who Have Completed a Previous Oncology Study With Olaparib (ROSY-O)
Prior participants of ROSY-O study
UPCC 22918: A Phase 1 Study Exploring the Safety Tolerability Pharmacokinetics and Pharmacodynamics of INCB086550 in Participants with Advanced Solid Tumors
The purpose of this Study is to test the safety and tolerability of the INCB086550 and to find out what effects, if any, the INCB086550 has on people and their cancer. The INCB086550 has been tested in animals but not yet in people. This Study will test different doses of …
Intramolecular Imaging with ICG (PRIME)
The purpose of this protocol is to monitor the rate of recurrence in patients who undergo cancer surgery. Patient diagnosed with solid tumor cancers have a high rate of recurrence when surgery is a treatment. The high rates of recurrence suggest that surgeons are unable to completely detect and remove …
LODESTAR: Study of Rucaparib as Treatment for SoliD Tumors Associated with DEleteriouS MuTations in Homologous RecombinAtion Repair Genes
This is a Phase 2 multicenter, open-label study evaluating rucaparib as treatment for solid tumors associated with a deleterious mutation in Homologous Recombination Repair (HRR) genes. All patients will be required to have received prior treatment with at least 1 line of life-extending therapy (if available) or have a tumor …
Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®22841 Monotherapy and in Combination with Pembrolizumab in Subjects with Selected Advanced Solid Tumors (DUET-4)
This is a Phase 1, multiple-dose, ascending dose-escalation and expansion study of XmAb22841, both as a monotherapy and in combination with pembrolizumab. The study is designed in 2 parts, Part A and Part B. Part A is a 3 + 3 dose escalation designed to assess both XmAb22841 administered as …
Study of ASTX295 in Patients With Solid Tumors With Wild-Type p53
ASTX295 is a synthetic small molecule that acts as an antagonist of Murine Double Minute 2 (MDM2; human homolog also known as HDM2). Study ASTX295-01 is a study with ASTX295 in subjects who are refractory or have relapsed after treatment with standard of care therapies, or for whom standard life-prolonging …
Observation of Residual Cancer With Liquid Biopsy Evaluation (ORACLE)
The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA test results are linked to clinical outcomes in order to demonstrate clinical validity for recurrence detection and …
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