Found 30 Dementia trials
A listing of Dementia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Since its launch in 2004, the overarching aim of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI1, ADNI-GO, and ADNI2 studies that have been combined public/private collaborations between academia and industry to determine the …
The study is at the Penn Memory Center at the University of Pennsylvania and is under the direction of David Wolk, M.D.. We are currently recruiting normal control participants ages 75 years and older. The purpose of this study is to collect, store and analyze cognitive data and biological samples, …
PET/CT imaging will be used to evaluate neuroinflammation in subjects with Alzheimer's Disease and Healthy Controls, using the investigational radiotracers [11C]PBR28 and[18F]NOS. Each subject will have one PET/CT session that includes both [11C]PBR28 and [18F]NOS injections and scan of the brain performed sequentially. Subjects may also undergo a brain MRI …
The purpose of this clinical study is to learn about the safety of CT1812 and how well your body tolerates a once-a-day dose of CT1812. The study will also test how well CT1812 will treat mild to moderate dementia with Lewy Bodies.
The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal …
This research is being done to study a new way to treat FTD in patients who have the GRN mutation. This process is called “gene therapy”. Gene therapy is an experimental technique that aims to replace the gene that is not working properly with a version of the gene that …
The purpose of this study is to identify the relationship between chronic sleep disturbance and proteins in spinal fluid that are related to dementia and a molecule called orexin that helps regulate wakefulness and appetite in the brain. Individuals with sleep problems and good sleepers will be asked to participate.
To collect Tau PET imaging in cognitively normal older African American (AA) adults in the ABCD2 study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the mechanisms and distinctions of age-related cognitive decline and that of Alzheimer's disease. Eligible …
We are conducting research studies on how immune system cells contribute to inflammatory conditions of the nervous system, such as multiple sclerosis, neuromyelitis optica (NMO), encephalitis, head injury, epilepsy, Parkinson's disease (PD), Alzheimer's disease (AzD), Lou Gherig's disease (amyotrophic lateral sclerosis; ALS) frontotemporal dementia (FTD) and others. This includes investigating …
The goal of this research is to collect Tau PET imaging in cognitively normal older adults and patients with Mild Cognitive Impairment (MCI) in the NACC study, to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the mechanisms and distinctions …
