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Found 14 Depression trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 Computer-Assisted Therapy for Depression
18 years - 60 years
All genders
The purpose of this study is to learn more about the treatment success of Computer-augmented Cognitive Behavioral Therapy (CCBT) and examine the neural connections of patients with depression via functional Magnetic Resonance Imaging (fMRI) scans.Computer-augmented Cognitive Behavioral Therapy (CCBT) is approved by the FDA as a form of treatment for …
18 years - 74 years
All genders
Phase 3
Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients with Major Depressive Disorder with Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy and an Open-labeled Long-term Safety Extension Treatment with Seltorexant
 Clinical Study to Evaluate the Efficacy and Safety of MK-1942 Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression
18 years - 65 years
Male
Phase 2
Normal 0 false false false EN-US X-NONE AR-SA This research study invites participants that are taking an antidepressant that has not fully helped with their depression. MK-1942 is the investigational product under study in this research trial, the participant will be taking along with their current antidepressant to test its …
18 years - 50 years
All genders
This research study is being conducted to learn more about how brain stimulation [transcranial magnetic stimulation (TMS)] affects the communication between brain regions. TMS is a new treatment that is starting to be used to treat depression and other psychiatric disorders. However, we do not have a good idea for …
18 years - 65 years
All genders
The purpose of this study is to explore possible neurological complications resulting from prior COVID-19 infection. Neurological symptoms, including ‘brain fog’, depression, and/or anxiety can be disabling. This study aims to determine the prevalence and severity of these symptoms. Unfortunately, little is known about these neuropsychiatric symptoms, particularly in patients …
99 years or below
All genders
This is an OL, multicenter, long-term study to evaluate the safety and efficacy of aticaprant 10 mg in combination with an oral antidepressant in adult and elderly participants with MDD and who have had an inadequate response to an SSRI or SNRI in the current depressive episode. Participants will enter …
99 years or below
All genders
Phase 1
This dual-site, double-blinded, randomized, sham-controlled, crossover study is to assess the safety, feasibility, and preliminary efficacy of SEEG-guided multi-lead DBS in 10 participants suffering from severe symptoms of chronic, treatment-refractory OCD. Stage 1: Invasive SEEG Monitoring and Recovery Goal: To perform stimulation mapping studies and SEEG recordings, that aid in …
 Intensive TMS for Rapid Relief of Bipolar Depression Symptoms
18 years - 99 years
All genders
The research study is being conducted to test whether using high dose spaced theta-burst rTMS (a form of transcranial magnetic stimulation) produces a significant reduction in depressive symptoms compared with sham. This project will recruit patients aged 18-70 with symptoms of bipolar depression who have failed (or not shown signs …
18 years - 65 years
All genders
Interventional
The research study is being conducted to test the efficacy of a new psychotherapeutic strategy, closed loop real time fMRI neurofeedback, in reducing negative attention bias and depressive symptoms. Participants are being asked to voluntarily participate in a research study because they are between the ages 18-65 and currently experiencing …
99 years or below
All genders
Phase 3
this study is to evaluate the efficacy of each individual dose of esketamine nasal spray, 56 mg and 84 mg, compared with placebo nasal spray in improving depressive symptoms in participants with TRD, as assessed by the change from baseline in the Montgomery-Asberg Depression Rating Scale (MADRS) total score from …
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