Found 29 Alzheimer's Disease trials
A listing of Alzheimer's Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Four-Repeat Tauopathy Neuroimaging Initiative
New treatments that target the protein tau are beginning to enter human clinical trials. While tau-related therapies hold great promise for AD, clinical trials focusing on pure tauopathies are appealing because these diseases do not exhibit concurrent amyloid pathology. Pure 4 microtubule binding repeat (4R) tauopathies (4RT) include corticobasal degeneration …
Phenotype Genotype and Biomarkers 2 (PGB2)
The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA) and multisystem proteinopathy (MSP). More precisely, we want to identify the links that exist between …
Trial Ready #8009
The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including but not limited to frontotemporal dementia (FTD), primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA). More precisely, we want to identify biomarkers of ALS and related diseases. A biomarker …
UPenn Observational Research Repository on Neurodegenerative Disease (UNICORN)
The aim of this study is to create a repository of both cross-sectional and longitudinal data, including cognitive, linguistic, imaging and biofluid biological specimens, for neurodegenerative disease research and treatment.
Evaluation of In Vivo Neuroinflammation in Alzheimers Disease Using Novel Positron Emission Tomography (PET/CT) Imaging
PET/CT imaging will be used to evaluate neuroinflammation in subjects with Alzheimer's Disease and Healthy Controls, using the investigational radiotracers [11C]PBR28 and[18F]NOS. Each subject will have one PET/CT session that includes both [11C]PBR28 and [18F]NOS injections and scan of the brain performed sequentially. Subjects may also undergo a brain MRI …
PBFT02-001- Phase 1B Study to Assess a Single Dose of PBFT02 Delivered into Adult Subjects with Fronto-Temporal Dementia (FTD) and Mutations in the Progranulin Gene (GRN)
This research is being done to study a new way to treat FTD in patients who have the GRN mutation. This process is called “gene therapy”. Gene therapy is an experimental technique that aims to replace the gene that is not working properly with a version of the gene that …
Healthy volunteers for Neuroinflammatory research study
We are conducting research studies on how immune system cells contribute to inflammatory conditions of the nervous system, such as multiple sclerosis, neuromyelitis optica (NMO), encephalitis, head injury, epilepsy, Parkinson's disease (PD), Alzheimer's disease (AzD), Lou Gherig's disease (amyotrophic lateral sclerosis; ALS) frontotemporal dementia (FTD) and others. This includes investigating …
Linking Tau PET to Medial Temporal Lobe Subregions with High Resolution MRI
The goal of this research is to collect Tau PET imaging in cognitively normal older adults and patients with Mild Cognitive Impairment (MCI) in the NACC study, to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the mechanisms and distinctions …
Brain Arterio-Venous Metabolomic Profiling
The research study is being conducted to better understand brain metabolism, i.e. how the brain uses and consumes the various nutrients that are available in the blood. Changes in brain metabolism have been implicated in dementia and psychiatric disorders, as well as short- and long-term outcomes of traumatic brain injury …
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