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Found 23 dm-cardiovascular-medicine trials

A listing of dm-cardiovascular-medicine medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

99 years or below
All genders
This Post Approval Study is a multi-center, prospective, open label, single arm cohort study to evaluate the long-term safety, long-term effectiveness, and survival rate in subjects implanted with the remed System from the remed System Pivotal Trial. Up to 94 subjects will be enrolled at up to 21 sites in …
 Dapagliflozin Effect on symptoms and blomarkers in patients with Heart Failure (DEFINE-HF)
18 years - 100 years
All genders
Interventional
The purpose of this study is to find out if a drug called dapagliflozin would be effective in improving the blood tests and symptoms related to your heart failure.
 BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in Heart Failure with Preserved Ejection Fraction
18 years - 99 years
All genders
Phase 1
The purpose of the study is to compare how amlodipine versus metoprolol effect blood pressure in people with HFpEF.   While hypertension is the most common risk factor for HFpEF, there is little evidence on the potential role of common antihypertensive medications, specifically calcium channel blockers (like amlodipine) and β-blockers …
 Medtronic SMall Annuli Randomized To Evolut or Sapien Trial (SMART Trial)
18 years - 99 years
All genders
The purpose of this study is to collect information and compare the safety and performance of self-expanding (SE) versus balloon-expandable (BE) transcatheter aortic valve replacement (TAVR) in patients with a small aortic valve.Study participants will be randomized on a 1:1 basis to receive transcatheter aortic valve replacement (TAVR) with either …
 NONCOMPACT- International Consortium for Multimodality Phenotyping in Adults with Non-compaction
18 years - 99 years
All genders
This is a prospective, multicenter observational study to identify clinical, genetic and imaging predictors of clinical outcome in patients with suspected non-compaction cardiomyopathy Many healthy people have increased trabeculations without consequences, however, some may develop blood clots, heart rhythm disorders or heart failure later in life. Currently we cannot predict …
 FS-CAMP: Fed-State Cardiac Arteriovenous Metabolomic Profiling
18 years - 99 years
All genders
This study will enroll subjects who are coming in for a clinical EP procedure that involves the use of venous, coronary sinus, and arterial line placement. Our patient population is primarily from the surrounding urban and suburban region of Penn Medicine.  The research team plans to quantify cardiac metabolism during …
 Disrupt CAD III With the Shockwave Coronary IVL System
18 years - 99 years
All genders
The study design is a prospective, multicenter, single-arm, global IDE study to evaluate the safety and effectiveness of the Shockwave Medical Coronary Intravascular Lithotripsy (IVL) System in de novo, calcified, stenotic coronary arteries prior to stenting. Disrupt CAD III is being conducted as a staged pivotal study.
 Strategies in Patients undergoing repeat AF ablation
18 years - 99 years
All genders
Interventional
The aim of the proposed research project is to compare the efficacy of three different ablation strategies in patients with atrial fibrillation (AF) who are undergoing their first repeat catheter ablation for recurrent AF.
 CAPRICORN-19
18 years - 99 years
All genders
In this study, the Investigators at the University of Pennsylvania will assess organ-specific biomarker profiles (proteins and metabolites), in order to better understand biologic processes, the interplay between the heart and extracardiac organs, and their role in human disease, with an emphasis on cardiovascular disease. The study will specifically focus …
 JK07 in Subjects with Heart Failure with Reduced Ejection Fraction (HFrEF)
18 years - 80 years
All genders
Phase 1
Patients with Heart Failure with Reduced Ejection Fraction (HFrEF) will be invited to participate in this study. HFrEF is a condition in which the heart pumps a lower than normal amount of blood. The purpose of this study is to evaluate the safety and activity of the investigational product in …
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