Cancer31 non cancer (1243)

Study of Fast Breast MRI Screening After Breast-Conserving Therapy

Age
18 years - 82 years
Gender
Female
participants needed
184
Location
1
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Brief description of study

500 patients will be prospectively recruited to undergo a fast breast MRI examination. The women will be recruited for the study will meet the following criteria: 1. status post primary breast cancer treated with breast conservation therapy 3 years prior to recruitment 2. negative DBT examination six months prior to recruitment 3. all breast densities 4. clinically asymptomatic - no palpable masses, focalthickening, or clinically significant discharge We will identify these patients EPIC database utilizing the date of their last mammogram. The patients will be sent a letter explaining the study and the opportunity to enroll in the study. Interested patients may contact our research coordinators by the phone number provided in the letter. The study recruitment information will also be shared with referring physicians. Physicians may also directly refer patients to the study.

Detailed description of study

Women treated for primary breast cancer who undergo breast conservation therapy face an increased risk of developing a second breast cancer in the ipsilateral and the contralateral breast. Although mammographic screening is recommended annually, the sensitivity of mammography is limited in these patients due to the post treatment changes from previous surgery and radiation. We propose supplemental screening with an abbreviated form of breast MRI ("fast MRI") examination in addition to mammographic screening, in order to study whether we can detect subclinical disease that may not be detected on mammography or on physical examination. Several tumor characteristics correlate with overall survival such as the extent of local recurrence and the size of the local recurrence, with larger extent and increased size of local recurrence correlating with adverse survival. In addition, the shorter time interval to the ipsilateral breast cancer recurrence from completion of treatment, is associated with increased risk of developing distant metastasis and breast cancer mortality. We will assess additional cancer detection with fast MRI after negative mammography in the ipsilateral as well as the contralateral breast. The goal of the supplemental screening with fast breast MRI would be to detectsubclinical disease not detected on mammography and thus improve patient outcomes.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating
  • Age: 18 years - 82 years
  • Gender: Female

Inclusion Criteria:

  1. Status post primary breast cancer (both invasive and DCIS) treated with breast conservation therapy at least three years prior to recruitment
  2. Negative DBT examination within six months prior to recruitment
  3. All breast densities
  4. Clinically asymptomatic - no palpable masses or focal thickening, etc.

Exclusion Criteria:

  1. Patients who are pregnant or lactating.
  2. Patients who have not had a mammogram (digital breast tomosynthesis) in the past 6 months.
  3. Patients who are unwilling or unable to provide written informed consent.
  4. Patients symptomatic for breast disease (e.g. experiencing discharge, lumps, etc.).
  5. Recent breast surgery in the past two years including breast enhancements (e.g. implants or injections) benign surgical biopsies.
  6. Patients who are unable to receive an MRI with Gadolinium contrast.
  7. Patients who have not had an MRI of the breast within the past year.

The purpose of this research study is to learn whether a shortened breast MRI scan (“fast MRI”) can find breast cancer that is not seen on a recent mammogram in women who were treated for primary breast cancer with breast-conserving therapy at least 3 years ago and who currently have no breast symptoms.

Participants will have a fast breast MRI exam as an extra screening test after a negative digital breast tomosynthesis (3D mammogram). The MRI will use gadolinium contrast (a dye used to help the images show more detail). The study will look at whether the MRI finds additional cancers in either breast after a negative mammogram.

Who can participate:
Women may be able to participate if they:

  • Have had primary breast cancer (including invasive cancer or DCIS) and were treated with breast-conserving therapy at least 3 years ago
  • Have had a negative digital breast tomosynthesis (3D mammogram) within the past 6 months
  • Do not have breast symptoms, such as a lump, focal thickening, or significant discharge
  • Are able to receive a breast MRI with gadolinium contrast

Updated on 02 Oct 2026. Study ID: 117436

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