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Effects of opioid use disorder and non-fatal overdose on tau pathology; a [18F]PI-2620 PET/CT study

Effects of opioid use disorder and non-fatal overdose on tau pathology; a [18F]PI-2620 PET/CT study
Recruiting
18 years - 60 years
All
Phase 2
60 participants needed
1 Location

Brief description of study

This study is being conducted to learn more about how opioid use and opioid overdose affects tau levels in the brain. Tau is a protein in the brain that helps stabilize nerve cells structure. We will study tau levels in the brain using a type of Positron Emission Tomography (PET/CT) scan using a radioactive imaging drug called [18F]PI-2620.

If you agree to join the study, you will be asked to complete the following research procedures:
• A consent/screening visit with a medical history questionnaire, routine blood work, a urine drug screen, psychological assessments, and questionnaires to determine eligibility.
• [18F]PI-2620 PET/CT of the brain
• Placement of an intravenous (IV) line during the scan.
• Blood draws for research inflammatory markers or other testing.
• An MRI scan of the brain, which includes a structural scan of the brain and performing a memory task in the scanner.

Your active participation will last approximately 8 weeks.

There will be three groups of up to 20 participants each:

  • Group 1: individuals with Opioid Use Disorder (OUD) and a history of at least one opioid-related overdose in the past year that required naloxone treatment reversal
  • Group 2: individuals with OUD without a lifetime history of opioid-related overdose
  • Group 3: Healthy controls without a history of OUD
Individuals in groups 1 and 2 must be on stable dose of medication for OUD.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Opioid Use Disorder,opioid use,opiate use,overdose,healthy volunteer
  • Age: 18 years - 60 years
  • Gender: All


Updated on 09 Apr 2026. Study ID: 852095

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