The goal of this study is to establish a registry and biosample repository (defined as blood, urine, and tumor specimens in patients with a pathologically confirmed diagnosis of neoplasia receiving radiotherapy or photodynamic therapy (PDT). Radiation Oncology Registry (Required): The first part of this study is the Radiation Oncology Registry. The purpose of the registry is to collect information on individuals undergoing radiation therapy and to use this clinical information for future research purposes. Participation in this portion of the study requires no additional obligations on your part; your participation means you are granting permission for your doctors to extract information from your medical chart and use this data for research purposes. Should any findings from this research be presented or published, your name, date of birth, or any other personal identifying information will not be included. Biosample Repository: Blood and stool collection are required for participation in this study. We will be collecting your blood and stool at up to five different time points and storing it in the Radiation Oncology Biosample Repository here at the University of Pennsylvania. All samples will be collected at your normal appointment times. These samples will be used for current or future research to study cancer. We are hoping that research using these samples will develop better methods to detect tumors, help patients have a better response to treatment, and reduce the side effects of cancer treatment.

You may be eligible for this study if you meet the following criteria:

• Conditions: Cancer,Oncology,Tumor
• Age: 18 years - 99 years
• Gender: All